Photosensitive skin reactions occur when human skin reacts to ultraviolet radiation or visible light abnormally. The forms of photosensitivity are phototoxicity and photoallergy. Phototoxic disorders have a high incidence, whereas photoallergic reactions are much less frequent in human population. Several hundred substances, chemicals, or drugs may invoke phototoxic and photoallergic reactions. In order to avoid photosensitive reactions it is essential to determine the photosensitizing properties of such substances before drugs are introduced in therapy or products made available on the market. The article reviews the mechanisms of photosensitization, explains the most important differences between phototoxic and photoallergic reactions, summarizes the most common photosensitizers, and presents the clinical features and diagnostic procedures of phototoxic and photoallergic reactions.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Long-Term Observations on the European Photopatch Test Baseline Series (EPTBS) in Real Clinical Practice: 11 Years of Results in a Spanish Cohort and Suggestions for an EPTBS Update.
Contact Dermatitis
December 2024
Department of Dermatology, Hospital Clínic de Barcelona, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Background: The European Photopatch Testing Baseline Series (EPTBS) was published in 2013. However, limited data exist regarding the real-world clinical application of the EPTBS.
Objectives: This study aims to describe the photopatch test experience with the EPTBS over 11 years at a tertiary hospital in Spain.
Topical Sunscreens: A Narrative Review for Contact Sensitivity, Potential Allergens, Clinical Evaluation, and Management for their Optimal Use in Clinical Practice.
Indian Dermatol Online J
October 2024
Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.
Topical sunscreens decrease the quantity of ultraviolet (UV) light from the sun reaching the skin by either blocking or scattering it and help protect the skin from dyspigmentation, photoaging, DNA damage, and photocarcinogenesis, especially in photosensitive individuals. The significant role played by visible light and infrared light in skin pigmentation and photoaging has been recognized in recent years. The majority of broad-spectrum sunscreens protect against UV-B (290-320nm) and UV-A (320-400nm) radiation.
View Article and Find Full Text PDFSurprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen.
Contact Dermatitis
December 2024
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Objective: Photoallergic reactions due to topical ketoprofen are common. As some simultaneous contact allergies have been described in the literature, we aimed to get an overview of the pattern of reactivity towards common allergens in the baseline series in ketoprofen-photoallergic individuals.
Methods: Using our database, we found 94 patients with photocontact allergy to ketoprofen diagnosed during 1999-2018.
Photopatch testing: Clinical characteristics, test results, and final diagnoses from the North American Contact Dermatitis Group, 2009-2020.
Contact Dermatitis
December 2024
Department of Dermatology, University of Colorado, Aurora, Colorado, USA.
Article Synopsis
- Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction triggered by allergens only when exposed to UV light, requiring photopatch testing (PhotoPT) for diagnosis.* -
- A study from 2009-2020 involving 454 patients revealed that most were women, aged 21-60, and the majority were White; results showed 119 positive tests, predominantly related to sunscreen agents like benzophenones.* -
- Among the diagnosed conditions, approximately 17.2% of patients had PACD, while other diagnoses included allergic contact dermatitis, polymorphous light eruption, and chronic actinic dermatitis, highlighting the need for photopatch testing in these cases.*
Drug-induced photosensitivity associated with anticancer therapies.
Ital J Dermatol Venerol
October 2024
Department of Oncodermatology, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France.
Article Synopsis
- Anticancer treatments are effective but can lead to a variety of skin-related side effects, particularly skin photosensitivity, which worsens with sun exposure.
- A review of recent literature focused on specific skin reactions, including phototoxic and photoallergic responses, and other conditions linked to sunlight exposure from these therapies.
- While there is growing recognition of photosensitivity issues in cancer treatment, further research is needed to enhance understanding and develop tailored treatment plans for affected patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!