Cognitive predictors of response to treatment for depression in multiple sclerosis.

J Neuropsychiatry Clin Neurosci

Department of Medicine, University of California, CA, USA.

Published: October 2006

Cognitive impairment, particularly in the domain of executive functioning, has been demonstrated to predict poorer antidepressant medication treatment response. In this investigation, neuropsychological functioning was evaluated as a predictor of depression treatment response among 59 patients with multiple sclerosis. Performance on a Stroop task accounted for 28.7% of the variance in poorer pharmacologic antidepressant treatment response, as compared to less than 1% of the variance in two psychotherapy conditions. These results provide preliminary evidence to suggest that performance on neuropsychological measures may predict antidepressant treatment response in multiple sclerosis.

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http://dx.doi.org/10.1176/jnp.2006.18.3.356DOI Listing

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