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Pertussis vaccine and infantile spasms. | LitMetric

Pertussis vaccine and infantile spasms.

Vaccine

University of Ioannina, Medical School, Department of Child Health, Ioannina 45110, Greece.

Published: January 2007

AI Article Synopsis

  • A 12-week-old boy began experiencing jerking attacks after receiving his triple vaccine, and EEG results indicated hypsarrhythmia.
  • Treatment with intramuscular ACTH helped, and no issues arose until he was 9 years old when he was prescribed sodium valproate.
  • The second boy, a cousin of the first, experienced momentary blackouts at age 11 and was diagnosed with idiopathic epilepsy, also treated with sodium valproate, indicating a family tendency towards seizures.

Article Abstract

The boy (case 1) at the age of 12 weeks started having attacks and jercked after the first injection of triple vaccine (diphtheria, retanus and whole cell pertussis) The electro-encephalogram (EEG) confirmed the typical features of hypsarrhythmia. Intramuscular ACTH was commenced for 2 weeks. No problem was reported until the age of 9 years when he started having attacks of jercking. He was treated with sodium valproate. The boy of the second case was a first cousin of case 1. At the age of 11 years the boy had momentary black outs. The EEG showed findings of idiopathic epilepsy. Treatment with sodium valproate was commenced. The children of both cases belong to a family in which there is a trendency to seizures. It seems unlikely the triple vaccine produced the infantile spasms in case 1.

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Source
http://dx.doi.org/10.1016/j.vaccine.2006.08.002DOI Listing

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