Some parameters of triiodothyronine hormone-receptor complexes (HRC) interactions with DNA-cellulose were studied. The competition between DNA and polyribonucleotides for HRC was demonstrated. It was found that in a model system of RNA transport HRC stimulate the 3H-RNA liberation from the nuclei. The functional significance of HRC-RNA interactions is discussed.
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Mechanisms in thyroid eye disease - the TSH receptor interacts directly with the IGF-1 receptor.
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Thyroid Research Unit, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
The pathogenesis of Thyroid Eye Disease (TED) has been suggested as due to signal enhancement in orbital fibroblasts as a result of autoantibody-induced, synergistic, interaction between the TSH receptor (TSHR) and the IGF-1 receptor (IGF-1R). This interaction has been explained by a "receptor cross talk", mediated via β-arrestin binding. Here, we have examined if this interaction can be mediated via direct receptor contact using modeling and experimental approaches.
View Article and Find Full Text PDFDifferential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair.
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Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
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Br J Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, Hong Kong
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