The diagnosis and treatment of peripheral neuropathy from any cause has come to the forefront of the research community in the past few years. Both past and new diagnostic and treatment options have been and are being studied to better understand and properly treat this debilitating and sometimes devastating disease. One such advancement is the clinical use of quantitative sensory testing. To identify etiology of the neuropathy early, the testing instrument would need to identify changes throughout the course of the disease, have a normative database, and show a clear distinction between the absence or presence of disease. The pressure specified sensory device (PSSD) was developed in 1992 to painlessly investigate the cutaneous pressure thresholds quantitatively and accurately.
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http://dx.doi.org/10.1016/j.cpm.2006.05.005 | DOI Listing |
Alzheimers Dement
December 2024
University of Michigan Medical School, Ann Arbor, MI, USA.
Background: Cognitive changes affecting performance are subtle in early stages of Alzheimer's Disease (AD) and may emerge only with more complex tasks. Driving is a highly challenging instrumental activity of daily living, requiring higher order integration of cognitive skills. For example, driving on freeway entrance ramps requires heightened cognitive engagement such as rapid responses to fast-emerging traffic and sudden speed changes, combining sensory processing and manipulative actions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Queen Mary University of London, London, United Kingdom.
Background: Alzheimer's disease (AD) is associated with a range of non-cognitive symptoms that can be early or even presenting features. Better recognition of pre-diagnostic symptoms of AD would support improved early detection and diagnosis.
Method: To identify possible prodromal symptoms of AD, we systematically searched three electronic databases for prospective longitudinal studies to March 2023, that reported the risk of AD diagnosis associated with non-cognitive symptoms.
Food Chem
December 2024
Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, 1800 Lihu Ave, Wuxi 214122, Jiangsu, China.
Baijiu aged in Jiuhai container will produce a special Jiuhai-aroma, which has not been fully studied. In this study, check-all-that-apply method and quantitative descriptive analysis were used to characterize Jiuhai-aroma, and it was found that the aroma characteristics of herbs, spicy, cut hay and woody were prominent in Baijiu aged in Jiuhai container. According to the results of GC-O and quantification, 71 odorants were identified in Jiuhai sample.
View Article and Find Full Text PDFFront Neurol
December 2024
Department of Head and Neck Surgery and Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
The relative accessibility and simplicity of vestibular sensing and vestibular-driven control of head and eye movements has made the vestibular system an attractive subject to experimenters and theoreticians interested in developing realistic quantitative models of how brains gather and interpret sense data and use it to guide behavior. Head stabilization and eye counter-rotation driven by vestibular sensory input in response to rotational perturbations represent natural, ecologically important behaviors that can be reproduced in the laboratory and analyzed using relatively simple mathematical models. Models drawn from dynamical systems and control theory have previously been used to analyze the behavior of vestibular sensory neurons.
View Article and Find Full Text PDFPain Manag Nurs
December 2024
Brain and Pain lab, Institute of Psychology (IPsiUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain. Electronic address:
Purpose: Conditioned Pain Modulation (CPM) is a useful tool for testing the functionality of endogenous pain modulation. However, inconsistent results have been obtained in clinical populations, possibly due to the wide variety of CPM protocols used and the influence of demographic and psychological characteristics of the individuals assessed.
Methods: We tested the sensitivity and reliability of four commonly used CPM paradigms in a sample of 58 healthy participants.
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