[Inhibitors of mitochondrial permeability transition pore prevent apoptosis of dopaminergic neurons in the mesencephalon].

In the study the role of apoptosis in development of dopaminergic neuronal cell death within substantia nigra (parts compacta) and ventral tegmental area induced by 6-OHDA was investigated. It was found that intermittent hypoxia and the water-soluble vitamine E (Trolox) and melatonin, as antioxidants and inhibitors of mitochondrial permeability transition pore protect dopaminergic cells from cytotoxic effect of 6-OHDA. It is supposed that mitochondrial permeability transition pore plays an important role in apoptosis of neurons in the brain.