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The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases.
Discov Nano
January 2025
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Some of the most crucial turning points in the treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with the introduction of antimicrobials and vaccines. Drug resistance and poor effectiveness are key limitations that need to be overcome. Conventional liposomes have been explored as a delivery system for infectious diseases bioactives to treat infectious diseases to provide an efficient approach to maximize the therapeutic outcomes, drug stability, targetability, to reduce the side-effects of antimicrobials, and enhance vaccine performance where necessary.
View Article and Find Full Text PDFPrediction of tuberculosis-specific mortality for older adult patients with pulmonary tuberculosis.
Front Public Health
January 2025
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Background: This study aims to identify risk factors associated with tuberculosis-specific mortality (TSM) in older adult patients with pulmonary tuberculosis (TB) and to develop a competing risk nomogram for TSM prediction.
Methods: We conducted a retrospective cohort study and randomly selected 528 older adult pulmonary TB patients hospitalized in designated hospitals in Henan Province between January 2015 and December 2020. The cumulative incidence function (CIF) was calculated for both TSM and non-tuberculosis-specific mortality (non-TSM).
Correction to: Dual Radionuclide Therapy: The Synergistic Effects of [Tb]Tb-PSMA and [Lu]Lu-PSMA in Advanced Prostate Cancer Post [Lu]Lu-PSMA Failure.
Nucl Med Mol Imaging
February 2025
Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 11941 Al-Jubeiha, Amman, Jordan.
[This corrects the article DOI: 10.1007/s13139-024-00871-4.].
View Article and Find Full Text PDFHarnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review.
Nucl Med Mol Imaging
February 2025
Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Queen Rania Street, Al Jubeiha, Amman, 11942 Jordan.
Background this systematic review was conducted to assess the practical application of terbium radioisotopes, utilizing systematic search methodologies to identify relevant studies. Methods the databases of PubMed, Web of Science, and Scopus were systematically scoured, targeting the research on four terbium isotopes: Tb, Tb, Tb, and Tb. Various combinations of keywords related to terbium and its four radioisotopes were used in the search process.
View Article and Find Full Text PDFThe yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.
Epidemiol Infect
January 2025
Department of Epidemiology - Laboratório de Inferência Causal em Epidemiologia (LINCE-USP), School of Public Health, University of São Paulo, São Paulo, SP, Brazil.
The strategy of tuberculosis (TB) contact investigation is essential for enhancing disease detection. We conducted a cross-sectional study to evaluate the yield of contact investigation for new TB cases, estimate the prevalence of TB, and identify characteristics of index cases associated with infection among contacts of new cases notified between 2010 and 2020 in São Paulo, Brazil. Out of 186466 index TB cases, 131055 (70.
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