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Protective effect of metformin on the NG-nitro-l-arginine methyl ester (l-NAME)-induced rat models of preeclampsia.
Biochem Biophys Res Commun
December 2024
Department of Obstetrics, First Clinical College of Shanxi Medical University, Taiyuan, Shanxi Province, PR China. Electronic address:
Background: Preeclampsia (PE) is a complex multi-organ disorder characterized by systemic inflammation, endothelial dysfunction, and vasoconstriction, which manifests as hypertension, with or without proteinuria. Effective preventive strategies for PE are currently lacking in clinical practice, leading to significant morbidity and mortality among mothers and newborns.
Objective: This study aims to investigate the impact of metformin (MET) on the l-NAME-induced PE rat model, focusing on the mechanisms through which MET may exert its effects.
1,25-Dihydroxyvitamin D protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia.
Metabolism
January 2025
Department of Physiology, Harbin Medical University, Harbin 150081, P.R. China. Electronic address:
Background: Maternal vitamin D deficiency is associated with an increased risk of preeclampsia, a potentially life-threatening multi-system disorder specific to human pregnancy. Placental trophoblast dysfunction is a key factor in the development of preeclampsia, and the activation of NOD-like receptor protein 3 (NLRP3) inflammasome may play a crucial role in this process. Previous studies have suggested that vitamin D can exert beneficial effects by suppressing inflammasome activation, but the underlying mechanism has not been fully elucidated.
View Article and Find Full Text PDFInterleukin-6 (-174G/C), Interleukin-1β (-511 C/T), and Apolipoprotein B-100 (2488 C/T) Gene Polymorphism in Pre-Eclampsia.
Medicina (Kaunas)
August 2024
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 40100, Punjab, Pakistan.
: Pre-eclampsia (PE) is a pregnancy-specific condition characterized by significant health risks for pregnant women worldwide due to its status as a multi-organ disorder. High blood pressure (hypertension) with or without proteinuria is usually considered an initial clinical sign of PE. The pathogenesis of pre-eclampsia is highly complex and likely involves multiple factors, including poorly developed uterine spiral arterioles, immunological issues, placental ischemia or infarction, and genetic abnormalities.
View Article and Find Full Text PDFA dynamic prediction model for preeclampsia using the sFlt-1/PLGF ratio combined with multiple factors.
BMC Pregnancy Childbirth
June 2024
The People's Hospital of Yuyao, Zhejiang, 315400, China.
Objective: Preeclampsia (PE) is a pregnancy-related multi-organ disease and a significant cause of incidence rate and mortality of pregnant women and newborns worldwide. Delivery remains the only available treatment for PE. This study aims to establish a dynamic prediction model for PE.
View Article and Find Full Text PDFIs the Complement System Dysregulated in Preeclampsia Comorbid with HIV Infection?
Int J Mol Sci
June 2024
Optics and Imaging Centre, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Article Synopsis
- * Preeclampsia may arise due to abnormal maternal immune responses, potentially linked to the complement system, which is crucial for immune regulation but can also influence HIV infectivity negatively.
- * The review focuses on the complex relationship between complement proteins, HIV, and preeclampsia in South Africa, aiming to identify high-risk women for better diagnosis and treatment outcomes.
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