Monte Carlo simulations are increasingly used to predict pharmacokinetic variability of antimicrobials in a population. We investigated the sample size necessary to provide robust pharmacokinetic predictions. To obtain reasonably robust predictions, a nonparametric model derived from a sample population size of >/=50 appears to be necessary as the input information.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635223 | PMC |
| http://dx.doi.org/10.1128/AAC.00337-06 | DOI Listing |
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