Background: The provision of health care is inseparable from universal values such as caring, helping and compassion. Consideration for individual values, particularly those of the patient, has also been increasing. However, such consideration is difficult within the context of modern health care, where complex and conflicting values are often in play. This is particularly so when a patient's values seem to be at odds with evidence-based practice or widely shared ethical principles, or when a health professional's personal values may compromise the care provided.
Suggested New Framework: Values-based practice, a framework developed originally in the domain of mental health, maintains that values are pervasive and powerful parameters influencing decisions about health, clinical practice and research, and that their impact is often underestimated. Although it shares starting points with other approaches to values, it suggests that our current approaches lead us to ignore some important manifestations of values at both the general level, as relevant in legal, policy and research contexts, as well as at the individual level, as relevant in clinical practice. Drawing on ideas from philosophy, values-based practice significantly extends the range of phenomena that may be regarded as value-laden. It suggests that one of the reasons for overlooking values is that they are presumed to be shared when not apparently conflicting. Values-based practice is an approach to supporting clinical decision-making, which provides practical skills and tools for eliciting individual values and negotiating these with respect to best available evidence.
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Biologics
December 2024
Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
Introduction: The translation of traditional Chinese medicine (TCM), which is experience-based, into evidence-based frameworks of Western medicine poses significant challenges due to differences in conceptualization, diagnosis, and evaluation methodologies. A critical need exists to bridge these disparities to enhance the integration of TCM into modern medical practices.
Methods: This study proposes a novel statistical methodology, leveraging confidence interval-based mapping, to calibrate subjective TCM diagnostic outcomes (eg, instruments or questionnaires) with objective Western clinical endpoints (eg, analytical test results).
Clin Biochem
December 2024
Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
Introduction: Serum cystatin C (CysC) is used to estimate glomerular filtration rate (eGFR), including in the Chronic Kidney Disease in Children (CKiD) Under 25 years (U25eGFR) equations. Several CysC measurement procedures available from diagnostic vendors include reference material for calibration, but the extent of heterogeneity across manufacturers is unclear. Since heterogeneity may have clinical and research implications for eGFR, we evaluated three CysC procedures in samples from the CKiD study representing a wide spectrum of kidney function.
View Article and Find Full Text PDFEnviron Res
December 2024
School of Environmental Ecology and Biological Engineering, Institute of Changjiang Water Environment and Ecological Security, Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address:
Aquaculture systems contribute to atmospheric NO, but the magnitude of this NO source is largely uncertain. Here, we synthesized data from 139 aquaculture sites based on 59 peer-reviewed publications, and estimated that China's aquaculture systems emitted 9.68 Gg N yr (4.
View Article and Find Full Text PDFJ Inflamm Res
December 2024
Department of Pediatric Immunology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People's Republic of China.
Background: Intravenous immunoglobulin (IVIG) resistance may be an increased risk of coronary artery lesions which is the serious complication of Kawasaki disease (KD). Early and accurate identification of IVIG-resistant patients has an important clinical value.
Objective: To establish a new predicting model by detecting the pyroptosis markers with other clinical indicators.
Encephale
February 2025
Laboratoire de psychopathologie et processus de changement, université Paris 8, 2, rue de la Liberté, 93200 Saint Denis, France.
There is a tension in contemporary clinical care between generalization, as required in the scientific process of evidence-based medicine, and personalization, as required for the autonomy and care's meaning of an always unique patient. We present here some of the key elements of values-based practice, a shared decision-making process that aims to reconcile these two major trends in clinical care. Values practice is rooted in pioneer work about values from 'ordinary language' analytic philosophy (the 'Oxford School').
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