AI Article Synopsis
- Active and silenced chromatin domains are located near each other, with enhancer and silencer elements influencing genes over large distances.
- The specific functions of these elements indicate the presence of active mechanisms that limit their effects.
- Insulators, which are DNA elements that restrict long-range regulatory actions, have been found to cluster in the nucleus and share common features across different organisms.
Article Abstract
Active and silenced chromatin domains are often in close juxtaposition to one another, and enhancer and silencer elements operate over large distances to regulate the genes in these domains. The lack of promiscuity in the function of these elements suggests that active mechanisms exist to restrict their activity. Insulators are DNA elements that restrict the effects of long-range regulatory elements. Studies on different insulators from different organisms have identified common themes in their mode of action. Numerous insulators map to promoters of genes or have binding sites for transcription factors and like active chromatin hubs and silenced loci, insulators also cluster in the nucleus. These results bring into focus potential conserved mechanisms by which these elements might function in the nucleus.
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| http://dx.doi.org/10.1146/annurev.genet.39.073003.113546 | DOI Listing |
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