Objective: To assess the potential impact over 10 years of a partially effective HIV vaccine in a cohort of 15-year-old adolescent girls in South Africa in terms of HIV infections and deaths prevented in mothers and infants.
Methods: A computer simulation was constructed using a population of all 15-year-old adolescent girls in South Africa followed for 10 years. A partially effective vaccine is introduced into this population with the ability to reduce the HIV incidence rates of the adolescents and vertical transmission to their infants through birth and breast-feeding. At the end of this 10 year period, the number of HIV infections and death prevented in adolescents and infants is analyzed.
Results: Using a 5% HIV incidence rate, a 50% effective vaccine decreases the number of HIV cases among adolescents by 57,653 (28.7%) and the number of cases among infants by 13,765 (28.9%) over 10 years. In addition, assuming a vaccine cost of $20 per dose, the vaccination program can save approximately $120 million for the South African government over 10 years.
Conclusion: A partially effective HIV vaccine has an important role in HIV prevention in adolescents and infants in South Africa irrespective of other public policy implementations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.qai.0000230526.79341.83 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Andrographolide Mitigates Cisplatin Resistance by Inhibiting SPP1 Regulated NF-kB/iNOS/COX-2 and PI3K/AKT Pathway in Cisplatin Resistant Cervical Carcinoma Cells.
Drug Dev Res
February 2025
Department of Genetics & Biotechnology, University College of Science, Osmania University, Hyderabad, Telangana, India.
Drug resistance and cancer recurrence are major cause of Cervical cancer (CC) patient mortality. Cisplatin (CDDP) is the major drug that has been extremely used in all stages in treating CC, although relapse and malignant instances have been observed as a result of cisplatin resistance in CC. In the present study, we established Cisplatin resistant CC HeLa cell line model and the cytotoxic effects of Andro as a single agent or in combination with CDDP were investigated to assess its potential as a chemotherapeutic agent in cisplatin-resistant HeLa (CisR-HeLa) cells.
View Article and Find Full Text PDFThe Effects of Resigning GPs on Patient Healthcare Utilization and Some Implications for Health.
Health Econ
January 2025
RWI Essen, Essen, Germany.
We study the effects of general practitioners' (GPs') resignations on their patients' healthcare utilization and diagnoses in an event-study setting. Using claims data from a large German statutory health insurance, we find that after physicians leave, their former patients persistently reduce their primary care utilization, only partially substituting it with specialist visits and hospital care. Because patients find a new GP already 1.
View Article and Find Full Text PDFCAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK-Mediated Autophagy.
Aging Cell
January 2025
Department of Nephrology, Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Renal proximal tubular epithelial cell (PTEC) senescence and defective autophagy contribute to kidney aging, but the mechanisms remain unclear. Caveolin-1 (CAV1), a crucial component of cell membrane caveolae, regulates autophagy and is associated with cellular senescence. However, its specific role in kidney aging is poorly understood.
View Article and Find Full Text PDFAccelerating the Zn Transport Kinetics in the Pre-Solvated Artificial Protective Layer via Preferential Electrostatic Interactions for Stable Zinc Anode.
Small
January 2025
Key Lab for Spec ial Functional Materials of Ministry of Education, National & Local Joint Engineering Research Center for High Efficiency Display and Lighting Technology, School of Nano Science and Materials Engineering, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng, 475 004, P. R. China.
The intrinsic safety and cost-effectiveness of the aqueous zinc ion batteries hold the potential for grid-scale energy storage. However, the uncontrolled dendrite growth, parasitic reactions, and electrochemical corrosion of the anode due to the random Zn transport near the anode hinder its practical applications. Herein, a pre-solvated artificial protective layer (ps-APL) with a nitrogen-containing functional group is constructed by an in situ polymerization strategy to stabilize the Zn anode via boosted Zn mass transport kinetics and oriented exposure of the Zn(002) facets.
View Article and Find Full Text PDFSelf-Adaptive Polarized Photoresponse in Organic Single-Crystal Phototransistors for Bionic Night-Time Polarization Perception.
Adv Mater
January 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
The emerging semiconductor micro/nanocrystals with intrinsic anisotropy have provided new perspectives for low-cost and simplified polarimetry. However, the low polarization sensitivity of state-of-the-art polarimeters based on anisotropic semiconductors under weak and partially polarized light severely hinders their practical application in complex dim environments. Here, a photo-adaptive polarization-sensitive organic phototransistor (POL-OPT) is demonstrated for bionic weak-light polarization perception.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!