In vitro destruction of carboxymethylcephades (CMC) polymer, its based polymer isoniazid produced, and the in vivo remedial and long effect of the latter on a tuberculous process were studied. It was found that a polymer isoniazid in blood plasma gradually degraded by 80% within 5-6 days. The experiments on animals demonstrated a minimum reactive action of CMC capable of gradually biodegrading in the tissues. A possible treatment of tuberculosis with a polymer isoniazid administered once every week is shown.
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Polim Med
December 2024
Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poland.
Acta Crystallogr C Struct Chem
October 2024
Grupo de Cristalografia Química (GCQ), Departamento de Química, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, Brazil.
Nanoscale
September 2024
Pharmaceutical Nanotechnology lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab, 140306, India.
Central nervous system tuberculosis (CNS-TB) is a severe form of extra-pulmonary tuberculosis with high mortality and morbidity rates. The standard treatment regimen for CNS-TB parallels that of pulmonary TB, despite the challenge posed by the blood-brain barrier (BBB), which limits the efficacy of first-line anti-TB drugs (ATDs). Nose-to-brain (N2B) drug delivery offers a promising solution for achieving high ATD concentrations directly at infection sites in the brain while bypassing the BBB.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
August 2024
Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.
In this study, the adsorption of a mixture of high-consumed drugs onto virgin and aged PET microplastics has been studied for the time ever. The target mixture comprised two anti-inflammatory drugs, diclofenac and ketoprofen, one anti-hypertensive, valsartan, and four common antibiotics, indomethacin, trimethoprim, isoniazid, and metronidazole. Two types of PET MPs (virgin and UV-aged) were used in the experimental procedure.
View Article and Find Full Text PDFDalton Trans
July 2024
SSPC The Science Foundation Ireland Research Centre for, Pharmaceuticals, Ireland.
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