AI Article Synopsis
- The study explored how rhBMP-2 affects new bone and cartilage formation in cricoid cartilage defects in rabbits.
- Fifteen rabbits were used, divided into three groups, with some receiving rhBMP-2 treatment and others serving as controls, with analysis done at different healing intervals.
- Results showed that rhBMP-2 treatment led to early signs of bone and cartilage healing, with well-structured bone present by four weeks, indicating effective repair processes.
- The findings highlight the potential of using rhBMP-2 in treating airway cartilage defects.
Article Abstract
Objective: The ultrastructural characteristics of new bone and cartilage, induced at the site of cricoid cartilage defects treated with rhBMP-2 in rabbits, were investigated.
Study Design And Setting: A cricoid defect model was used. Fifteen rabbits were randomly and equally divided into 3 groups. Four rabbits from each group were treated with rhBMP-2, while one rabbit from each group was used as control. The rabbits were killed 1, 2, or 4 weeks after surgery. The healing pattern of the laryngeal wound was evaluated by light and transmission electron microscopy.
Results: Mineralized collagen type I matrix, osteoblasts, and osteoclast-like cells were present as early as 1 week after surgery. Well-structured bone trabeculas and growth plate-like structures were present 4 weeks after surgery.
Conclusion: Intramembranous and endochondral osteogenesis take place at the site of cricoid cartilage defects treated with rhBMP-2. Progenitor cells of cricoid perichondrium form a growth plate-like structure similar to the epiphyseal growth plate.
Significance: This study reveals the pattern of BMP-2-induced repair of airway cartilage defects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.otohns.2006.04.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!