The purpose of this investigation was to evaluate the feasibility of a nanocrystalline hydroxyapatite compound in the treatment of calcaneal fractures with osseous defects after reduction. The study included 21 patients, representing 24 closed intraarticular calcaneus fractures with large defects remaining after operative reduction. All cases were supplemented with the hydroxyapatite bone substitute and stabilized with a calcaneal honeycomb plate. Radiographs were taken at 6 weeks, 12 weeks, 6 months, and 1 year postoperatively, with specific attention given to measurement of Gissane's angle, Böhler's angle, and calcaneal height. A postoperative subjective and objective evaluation of the fracture, using the Creighton Nebraska Health Foundation scale, was performed 1 year postoperatively. Böhler's angle improved from a mean 8.6 +/- 5.3 degrees preoperatively to an immediate postoperative mean result of 31.5 +/- 6.5 degrees and 27.7 +/- 8.6 1 year postoperatively. The mean Creighton-Nebraska functional score was 86 +/- 10 at the 1-year follow-up evaluation. These results suggest that open reduction with plate fixation combined with nanocrystalline hydroxyapatite augmentation presents a good and reliable surgical technique for treatment of calcaneus fractures.
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http://dx.doi.org/10.1053/j.jfas.2006.05.006 | DOI Listing |
Dent J (Basel)
November 2024
Department of Orthodontics, Rostock University Medical Centre, Strempelstrasse 13, 18057 Rostock, Germany.
Extensive and closely coordinated remodeling processes take place in the periodontal ligament (PDL) and the adjacent bone during orthodontic tooth movement. In complex orthodontic cases, it is necessary to move teeth into an augmented bony defect, for example, in patients with cleft lip, alveolus, and palate. The important role of the PDL during tooth movement is well accepted but not fully understood.
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
October 2024
Departamento de Nanotecnología, Centro de Física Aplica y Tecnología Avanzada, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Querétaro, Mexico.
The aim of this work is to investigate the changes in the physicochemical properties of hydroxyapatite (HAp) extracted from horse humerus bones of different ages (1, 3, 6, and 8 years) subjected to low temperature calcination (600°C). Thermal analysis revealed significant mass loss due to water, collagen, organic compounds, carbonates, and age-related magnesium out-diffusion. Higher fat content in older bones contributed to increased mass loss.
View Article and Find Full Text PDFACS Biomater Sci Eng
October 2024
Department of Materials Science and Engineering Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
The repair of critical-sized bone defects remains a major challenge for clinical orthopedic surgery. Here, we develop a surface biofunctionalized three-dimensional (3D) porous polyether-ether-ketone (PEEK) scaffold that can simultaneously promote osteogenesis and regulate macrophage polarization. The scaffold is created using polydopamine (PDA)-assisted immobilization of silk fibroin (SF) and the electrostatic self-assembly of nanocrystalline hydroxyapatite (nano-HA) on a 3D-printed porous PEEK scaffold.
View Article and Find Full Text PDFBiomimetics (Basel)
July 2024
Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 11, 1113 Sofia, Bulgaria.
Simulated body fluid (SBF) and artificial saliva (AS) are used in biomedical and dental research to mimic the physiological conditions of the human body. In this study, the biomimetic precipitation of double-doped amorphous calcium phosphate in SBF and AS are compared by thermodynamic modelling of chemical equilibrium in the SBF/AS-CaCl-MgCl-ZnCl-KHPO-HO and SBF/AS-CaCl-MgCl-ZnCl-KHPO-Glycine/Valine-HO systems. The saturation indices (SIs) of possible precipitate solid phases at pH 6.
View Article and Find Full Text PDFRSC Adv
August 2024
Shandong Provincial Engineering and Technical Center of Light Manipulations and Shandong Provincial Key Laboratory of Optics and Photonic Device, School of Physics and Electronics, Shandong Normal University Ji'nan 250014 China
Calcium phosphates (Ca-P) represent a significant class of biological minerals found in natural hard tissues. Crystallization through phase transformation of a metastable precursor is an effective strategy to guide the growth of crystalline Ca-P with exceptional functionality. Despite extensive research on Ca-P, the exact process during the crystallization of amorphous particles to hydroxyapatite (HA) remains elusive.
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