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Integrated intraoperative predictive model for malignancy risk assessment of thyroid nodules with atypia of undetermined significance cytology.
Sci Rep
January 2025
Department of Thyroid Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Management of thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytology is challenging because of uncertain malignancy risk. Intraoperative frozen section pathology provides real-time diagnosis for AUS/FLUS nodules undergoing surgery, but its accuracy is limited. This study aimed to develop an integrated predictive model combining clinical, ultrasound and IOFS features to improve intraoperative malignancy risk assessment.
View Article and Find Full Text PDFFluorescence microscopy of parathyroid and thyroid tissues for localization of autofluorescent substances using near-infrared wavelengths.
Auris Nasus Larynx
January 2025
Department of Otolaryngology, Kameda Medical Hospital, Chiba, Japan.
Objective: The parathyroid gland emits autofluorescence with a peak at 822 nm when excited using near-infrared light at 785 nm; this observation of autofluorescence using a near-infrared detection device is useful for identifying the parathyroid gland during surgery. We aimed to clarify the localization of autofluorescent substances in parathyroid and thyroid tissues by observing them under a fluorescence microscope through filters that selectively pass specific near-infrared wavelengths.
Methods: Four cases of parathyroid and three cases of thyroid were examined under a fluorescence microscope.
Immunohistochemical examination of PNAd, α4β1 integrin and MUC-2 expressions in the secretary phase endometrium of women diagnosed with recurrent implantation failure.
J Reprod Immunol
December 2024
Department of Histology and Embryology, Medical School, University of Cukurova, Adana, Turkiye.
Objective: Successful embryo implantation is contingent upon the intricate interaction between the endometrium and the blastocyst. Recurrent implantation failure (RIF) signifies the clinical challenge of failing pregnancy post-transfer of high-quality embryos, fresh or frozen, in at least three in vitro fertilization (IVF) cycles, often in women under 40 years. Recent studies identify impaired blastocyst maternal tissue communication among recurrent implantation failure causes.
View Article and Find Full Text PDFRelationship Between Metabolic Profile, Pain, and Functionality in Patients with Frozen Shoulder: A Cross-Sectional Study.
Healthcare (Basel)
December 2024
Clinical Psychoneuroimmunology, University of Granada and PNI Europe, 52004 Melilla, Spain.
Article Synopsis
- Frozen shoulder (FS) is a painful condition that limits shoulder movement, and this study looks at how liver enzymes and thyroid function relate to pain and shoulder function in FS patients.
- Researchers evaluated 32 patients' metabolic biomarkers through blood tests and assessed pain and functionality using the Shoulder Pain and Disability Index (SPADI).
- The study found that lower levels of certain liver enzymes (AST, ALT, GGT) and thyroid-stimulating hormone (TSH) were associated with higher pain scores, indicating that these metabolic factors may influence the severity of FS symptoms.
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