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Sleep Quality and Its Contributing Factors Among Patients With Obesity: A Cross-Sectional Study.
Cureus
November 2024
College of Medicine, Wenzhou Medical University, Wenzhou, CHN.
Background: Obesity is a major public health issue associated with a range of comorbid conditions, including sleep disturbances. Poor sleep quality is common in individuals with obesity, yet the factors contributing to this relationship remain underexplored, especially in non-Western populations. This study aimed to investigate sleep quality and its contributing factors among patients with obesity in the eastern region of Saudi Arabia.
View Article and Find Full Text PDFIntroduction: Caffeine is the registered pharmacologic treatment for apnea of prematurity and is extensively used in the neonatal intensive care units (NICUs) based on evidence from randomized controlled trials. This study aimed to describe the clinical use of caffeine based on real-world data, hypothesizing a divergence from the registered dosing regimen.
Methods: A retrospective analysis included infants born before 30 weeks of gestation, admitted to the NICU of the Erasmus MC Rotterdam from 2018 to 2021.
The association of gene polymorphisms of adenosine and dopamine receptors with the response to caffeine citrate treatment in infants with apnea of prematurity: a prospective nested case-control study.
Ital J Pediatr
October 2024
Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, Fujian, China.
Article Synopsis
- The study examines how variations in adenosine and dopamine receptor genes, along with clinical factors, affect how preterm infants respond to caffeine citrate treatment for apnea of prematurity (AOP).
- It analyzed data from 221 preterm infants, identifying 160 as responders to treatment and 61 as non-responders, while genotyping 22 genetic polymorphisms to compare outcomes.
- Findings showed that non-responders had higher rates of complications and specific genetic variations linked to poor response, while greater gestational age was identified as a protective factor; a predictive nomogram for treatment response was also developed.
Introduction of a single-nucleotide variant, rs16851030, into the gene increased cellular susceptibility to hypoxia.
Per Med
December 2024
Centre for Drug & Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia.
Rs16851030, a single-nucleotide variant located in the 3'-untranslated region of the gene, has been proposed as a potential marker of caffeine sensitivity in apnea of prematurity. Besides, it is associated with aspirin-induced asthma and the development of acute chest syndrome. However, its functional significance is still unconfirmed.
View Article and Find Full Text PDFPerinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
Stroke
November 2024
Department of Pediatrics (J.K.M., Y.W., J.H., A.I., C.H., R.S.H., C.V., H.M., J.L.-B., J.R.F., D.M.F., E.M.), University of California San Francisco.
Article Synopsis
- Neonatal hypoxic-ischemic encephalopathy primarily impacts low- and middle-income countries, with therapeutic hypothermia often proving ineffective, highlighting a need for earlier treatment strategies.
- A study involved administering perinatal caffeine to near-term lambs undergoing severe hypoxia-ischemia, assessing its pharmacokinetics, safety, and efficacy in improving outcomes.
- Caffeine administration enhanced neurodevelopmental results and decreased inflammation and gray matter damage, suggesting it could be a viable treatment for affected neonates compared to previous studies on other medications.
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