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Critical Structures of Bisphenol Analogues on Embryonic Toxicity Identified by a Computational Approach.
Environ Sci Technol
January 2025
School of Ecology and Environmental Science, Yunnan University, Kunming 650504, China.
Safer chemical alternatives to bisphenol (BP) have been a major pursuit of modern green chemistry and toxicology. Using a chemical similarity-based approach, it is difficult to identify minor structural differences that contribute to the significant changes of toxicity. Here, we used omics and computational toxicology to identify chemical features associated with BP analogue-induced embryonic toxicity, offering valuable insights to inform the design of safer chemical alternatives.
View Article and Find Full Text PDFCarotid artery atherosclerosis: mechanisms of instability and clinical implications.
Eur Heart J
January 2025
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Cardiovascular disease remains a prominent cause of disability and premature death worldwide. Within this spectrum, carotid artery atherosclerosis is a complex and multifaceted condition, and a prominent precursor of acute ischaemic stroke and other cardiovascular events. The intricate interplay among inflammation, oxidative stress, endothelial dysfunction, lipid metabolism, and immune responses participates in the development of lesions, leading to luminal stenosis and potential plaque instability.
View Article and Find Full Text PDFBridging the Gap: The Importance of Non-technical Skills in Cardiology for Enhanced Patient Care and Team Performance.
Cureus
December 2024
Acute Medicine, Portsmouth Hospitals University NHS Trust, Portsmouth, GBR.
Cardiology, a high-acuity medical specialty, has traditionally emphasised technical expertise, often overshadowing the critical role of non-technical skills (NTS). This imbalance stems from the historical focus on procedural competence and clinical knowledge in cardiology training and practice, leaving a significant gap in the development of crucial interpersonal and cognitive abilities. However, emerging evidence highlights the significant impact of NTS on patient outcomes, team dynamics, and overall healthcare efficiency.
View Article and Find Full Text PDFAnthropogenically induced climate change has significantly increased the frequency of acute weather events, such as drought. As human activities amplify environmental stresses, animals may be forced to prioritize survival over behaviors less crucial to immediate fitness, such as socializing. Yet, social bonds may also enable individuals to weather the deleterious effects of environmental conditions.
View Article and Find Full Text PDFA randomized, clinical trial of intravenous N-acetylcysteine as an antioxidant therapy in acute organophosphorus pesticide poisoning.
Toxicol Res (Camb)
January 2025
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 1181, Egypt.
The incidence of acute organophosphate (OP) poisoning has steadily increased in developing countries. Many studies showed that oxidative stress could have a significant role in its mechanism. The current study aimed to evaluate the role of N acetylcysteine (NAC) as an antioxidant in acute OP poisoned.
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