Study Design: Biomechanical study to investigate three-dimensional motion behavior of cadaveric spines in various surgical simulations.
Objectives: To determine the effect of cage geometry on the construct stability.
Summary Of Background Data: There is a wide variety of cage/spacer designs available for lumbar interbody fusion surgery. These range from circular, tapered, and rectangular with and without curvature. However, the effectiveness of cages with different designs and materials to stabilize a decompressed intervertebral space has not been fully studied.
Methods: Six fresh ligamentous lumbar spine specimens (L1-S2) were subjected to pure moments in the six loading directions. The resulting spatial orientations of the vertebrae were recorded using Optotrak Motion Measurement System. Measurements were made sequentially for intact, bilateral spacer placements across L4-L5 using a posterior approach, supplemented with pedicle screw-rod system fixation, and after the cyclic loading in flexion-extension mode.
Results: The stability tended to decrease after the bilateral cage placement as compared with the intact for all loading cases except flexion. In flexion, the angular displacement decreased to 80% of the intact. However, there was no significant statistical difference seen in stability between intact and after bilateral spacer placement. Following the addition of posterior fixation using pedicle screw-rod system, the stability significantly increased in all directions. Cyclic loading did not have any significant effect on the stability.
Conclusions: Stand-alone cages restore motion to near-intact levels at best, and supplement instrumentation is essential for significantly increasing the stability of the decompressed segment. The effects of cage geometry and Young's modulus of the cage material do not seem to influence the stability, as compared with the other cagedesigns, especially after supplemental fixation with a posterior system.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.brs.0000232720.23748.ce | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D polycatenated architected materials.
Science
January 2025
Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
Architected materials derive their properties from the geometric arrangement of their internal structural elements. Their designs rely on continuous networks of members to control the global mechanical behavior of the bulk. In this study, we introduce a class of materials that consist of discrete concatenated rings or cage particles interlocked in three-dimensional networks, forming polycatenated architected materials (PAMs).
View Article and Find Full Text PDFStructure and dynamics of piperidinium based amino acid ionic liquids: a computational investigation.
J Mol Model
January 2025
Department of Chemistry, Birla Institute of Technology and Science Pilani - K. K. Birla Goa Campus, Zuarinagar, 403726, Goa, India.
Context: There has been growing interest in amino acid ionic liquids because of their low-cost synthesis and superior biodegradability and biocompatibility compared to traditional ionic liquids. In this study, we have investigated the structure and dynamics of three ionic liquids consisting of N-butyl N-methyl piperidinium [Pip] cation with amino acid (lysine [Lys], histidine [His], and arginine [Arg]) anions. The radial distribution functions, the spatial distribution functions, and the coordination numbers have been used to analyze the structure in the bulk phase.
View Article and Find Full Text PDFInfluence of a Lordotic Cage Profile on Global and Segmental Lordosis in the Context of Lumbar TLIF Surgeries: A Retrospective Radiological Analysis.
J Clin Med
November 2024
Orthopädie Rickert, 63500 Seligenstadt, Germany.
Cage implantation decompresses neural elements, stabilizes segments, and promotes fusion, with sagittal balance influenced by cage size, geometry, and position. This retrospective study compared the effects of lumbar interbody cages with 10° and 15° lordotic angles on global and segmental lordosis in patients undergoing transforaminal lumbar interbody fusion (TLIF). Data from 215 patients who underwent 259 TLIF procedures between 2018 and 2022 were analyzed.
View Article and Find Full Text PDFSelf-assembling of coiled-coil peptides into virus-like particles: Basic principles, properties, design, and applications with special focus on vaccine design and delivery.
Biophys Chem
December 2024
Department of Biotechnology, Mahatma Gandhi Central University, Motihari 845401, India. Electronic address:
Self-assembling peptide nanoparticles (SAPN) based delivery systems, including virus-like particles (VLP), have shown great potential for becoming prominent in next-generation vaccine and drug development. The VLP can mimic properties of natural viral capsid in terms of size (20-200 nm), geometry (i.e.
View Article and Find Full Text PDFTunable synthesis of heteroleptic zirconium-based porous coordination cages.
Chem Sci
January 2025
Department of Chemistry, Indiana University Bloomington IN 47405 USA
Zirconium-based porous coordination cages have been widely studied and have shown to be potentially useful for many applications as a result of their tunability and stability, likely as a result of their status as a molecular equivalent to the small 8 Å tetrahedral pores of UiO-66 (Zr(μ-O)(μ-OH)(COH)). Functional groups attached to these molecular materials endow them with a range of tunable properties. While so-called multivariate MOFs containing multiple types of functional groups on different bridging ligands within a structure are common, incorporating multiple functional moieties in permanently microporous molecular materials has proved challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!