In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 microg/mL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2006.08.043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids.
Antioxidants (Basel)
January 2023
Department of Pharmacy, University "Gabriele d'Annunzio" of Chieti-Pescara, 66100 Chieti Scalo (CH), Italy.
A series of five naturally occurring oxyprenylated phenylpropanoids, namely, the coumarins auraptene (7-geranyloxycoumarin) and 7-isopentenyloxycoumarin , and the coumaric acid and ferulic acid derivatives, 4'-isopentenyloxycoumaric acid , boropinic acid , and 4'-geranyloxyferulic acid were tested for their effects on mitochondrial functionality using the organophosphate pesticides glyphosate and chlorpyrifos, and resveratrol, as the reference. While not showing an appreciable in vitro antioxidant activity, and virtually no or a little effect on the viability of non-cancer cell lines BEAS-2B and SHSY-5Y, all phytochemicals exhibited a marked protective effect on mitochondrial potential and activity, with values that were comparable to resveratrol. Auraptene and 7-isopentenyloxycoumarin were seen to be the most effective secondary metabolite to this concern, in particular in being able to completely abolish the decrease of mitochondrial potential induced by increasing concentration of both glyphosate and chlorpyrifos.
View Article and Find Full Text PDFModular Approach to Benzofurans, 2H-Chromenes and Benzoxepines via Claisen Rearrangement and Ring-Closing Metathesis: Access to Phenylpropanoids.
Chem Asian J
April 2022
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai, 400 076, India.
Benzofurans, 2H-chromenes and benzoxepines are key structural elements present in several natural products and pharmaceuticals. Here, we describe an easy-to-execute strategy for the synthesis of benzofurans, 2H-chromenes and benzoxepines, by employing Claisen rearrangement and ring-closing metathesis as key steps. A variety of phenols were converted into useful oxacycles in good to excellent yields.
View Article and Find Full Text PDFA novel and efficient subcritical butane extraction method and UHPLC analysis of oxyprenylated phenylpropanoids from grapefruits peels.
J Pharm Biomed Anal
May 2020
Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti - Pescara, Via dei Vestini 31, 66100, Chieti Scalo, CH, Italy.
Biologically active prenyoxyphenylpropanoids are well known to be biosynthesized by Citrus species, for which they have been found most abundantly in fruit peels. Although several extraction methodologies have been described, the development of novel and alternative extraction processes is a field of research of current interest. In this preliminary communication, we studied the performance of the subcritical butane promoted extraction of selected oxyprenylated phenylpropanoids from grapefruit peels under a counter-current mode using a handmade extraction apparatus coupled to UHPLC analysis.
View Article and Find Full Text PDFUmbelliprenin as a novel component of the phytochemical pool from Artemisia spp.
J Pharm Biomed Anal
May 2020
Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti - Pescara, Via dei Vestini 31, 66100 Chieti Scalo, CH, Italy.
Plants belonging to Artemisia spp. are known to biosynthesize a wide panel of 3,3-dimethylallyl- and sesquiterpenyl- substituted coumarins. In this short communication we applied a novel extraction methodology based on the use of subcritical butane under a counter-current mode to further characterize the presence of selected biologically active oxyprenylated phenylpropanoids, namely coumarins and ferulic acid derivatives, in extracts deriving from aerial parts of Artemisia vulgaris L.
View Article and Find Full Text PDFNovel biologically active principles from spinach, goji and quinoa.
Food Chem
March 2019
Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
Spinach leaves, goji berries and quinoa seeds are claimed to have a great nutraceutical potential due to their high content of compounds providing benefits for human health, such as amino acids, polyunsaturated fatty acids, carotenoids, betaine, vitamins, fibre, minerals and polyphenols. Samples of these plants were extracted with different solvent mixtures (e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!