AI Article Synopsis
- - Two new series of thienopyrrole inhibitors have been developed to target human liver glycogen phosphorylase a (GPa) to help lower glucose production from rat liver cells.
- - These inhibitors work by interacting with a specific site (the dimer interface) in the enzyme's structure, as revealed by X-ray crystallography studies.
- - The research highlights the potential of these compounds in managing glucose levels in the body, which could have implications for diabetes treatment.
Article Abstract
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.
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| http://dx.doi.org/10.1016/j.bmcl.2006.08.047 | DOI Listing |
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