We report six cases of Aspergillus meningitis after spinal anaesthesia for caesarean section administered in June and July 2005. Three patients died before a fungal infection was confirmed at the first post-mortem examination in August. Thereafter anti-fungal therapy was successful in saving the lives of the other three patients. Some syringes and spinal needles supplied to the hospitals concerned were found to be contaminated with Aspergillus fumigatus. Investigators found that medical supply storage facilities were substandard following the influx of donations after the tsunami of December 2004.
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http://dx.doi.org/10.1016/j.ijoa.2006.06.010 | DOI Listing |
Eur Rev Med Pharmacol Sci
April 2023
Department of Pharmacy, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Zhejiang Province, Hangzhou, China.
Background: Rifapentine is a rifamycin with unique bactericidal activity against Mycobacterium tuberculosis. It is also a potent inducer of CYP3A activity. However, the duration of rifapentine-induced hepatic enzyme activity after withdrawal is unclear.
View Article and Find Full Text PDFAlthough Aspergillus meningitis is poorly responsive to current guidelines for treatment, we describe a dramatic response of Aspergillus meningitis in a patient to treatment using a combination of corticosteroids with guideline's suggested antifungal agents. Administration of corticosteroids in patients with Aspergillus meningitis is rarely reported in previous studies.
View Article and Find Full Text PDFIndian J Pathol Microbiol
June 2021
Department of Rheumatology, Aster Medcity, Kochi, Kerala, India.
Aspergillus meningitis is a rare clinical entity that is much more frequently observed among immunocompetent patients. Here we present the case of a 28 year old immunocompetent lady with Aspergillus fumigatus meningitis possibly following spinal anaesthesia for her caesarean section. The diagnosis of Aspergillus meningitis is very difficult and challenging.
View Article and Find Full Text PDFJ Infect Chemother
June 2020
Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan.
Central nervous system aspergillosis is relatively rare and difficult to diagnose. Here, we report a case of 90-year-old man with chronic lymphocytic leukemia who presented with a month-long gradually worsening headache followed by 3 days of low-grade fever associated with altered mental status. Aspergillus meningitis diagnosed using Aspergillus galactomannan antigen in the cerebrospinal fluid and treated with voriconazole.
View Article and Find Full Text PDFNeurol Sci
March 2018
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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