Spectra and coherences are standard measures of association within and between time series. These measures have several advantages over their time-domain counterparts, not the least of which is the ability to derive and estimate confidence intervals. However, comparing spectra and coherences between two groups of observation is a problem that has not received much attention. This problem is important in neuroscience since it is often of great interest to determine whether the estimates differ between distinct experimental/behavioral conditions. Here we propose one approach to this problem. Based on the known distributional properties of spectral and coherence estimates, we derive a test for equality of two spectral or coherence estimates. The test is applicable to unequal sample sizes. We also derive jackknifed estimates of the variance of the proposed test statistic. We suggest that comparing the estimates obtained from the jackknife procedure with the theoretical estimates provides a robust means of determining whether the data in question shows non-Gaussian or non-stationary behavior. Finally, we present applications of the method to simulated and real data.
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http://dx.doi.org/10.1016/j.jneumeth.2006.07.011 | DOI Listing |
Sci Rep
January 2025
Department of Chemistry & Environmental Science, Jordan Hu College of Science and Liberal Arts, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Nanoparticles (NPs) have been successfully used as drug delivery systems. To develop and optimize NP-based drug delivery systems, it is essential to understand the dynamics of cell-NP interactions. Quantitative phase imaging techniques enable label-free imaging and have the potential to reveal how cells interact with NPs.
View Article and Find Full Text PDFNanophotonics
January 2025
Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Kasprzaka 44/52, Poland.
A combination of femtosecond stimulated Raman scattering and surface-enhanced Raman scattering, termed surface-enhanced stimulated Raman scattering (SE-FSRS), was proposed to leverage both temporal precision and sensitivity for advanced molecular dynamics analysis. During the initial successful implementations of this approach, unexpected spectral distortions were observed, and several potential explanations were proposed. Further progress in this novel technique and its broader implementation requires a profound understanding of the factors influencing the shape of the registered spectra and the underlying mechanisms.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
School of Chemistry, University of East Anglia, Norwich NR4 7TJ, U.K.
Understanding the role of structural and environmental dynamics in the excited state properties of strongly coupled chromophores is of paramount importance in molecular photonics. Ultrafast, coherent, and multidimensional spectroscopies have been utilized to investigate such dynamics in the simplest model system, the molecular dimer. Here, we present a half-broadband two-dimensional electronic spectroscopy (HB2DES) study of the previously reported ultrafast symmetry-breaking charge separation (SB-CS) in the subphthalocyanine oxo-bridged homodimer μ-OSubPc.
View Article and Find Full Text PDFJ Biophotonics
January 2025
Department of Electronic Engineering, Maynooth University, Kildare, Ireland.
Broadband CARS is a coherent Raman scattering technique that provides access to the full biological vibrational spectrum within milliseconds, facilitating the recording of widefield hyperspectral Raman images. In this work, BCARS hyperspectral images of unstained cells from two different cell lines of immune lineage (T cell [Jurkat] and pDCs [CAL-1]) were recorded and analyzed using multivariate statistical algorithms in order to determine the spectral differences between the cells. A classifier was trained which could distinguish the known cells with a 97% out-of-bag accuracy.
View Article and Find Full Text PDFSmall
January 2025
Faculty of Physics and Astronomy, Adam Mickiewicz University, Poznan, 61-614, Poland.
The behavior of triple-cation mixed halide perovskite solar cells (PSCs) under ultrashort laser pulse irradiation at varying fluences is investigated, with a focus on local heating effects observed in femtosecond transient absorption (TA) studies. The carrier cooling time constant is found to increase from 230 fs at 2 µJ cm⁻ to 1.3 ps at 2 mJ cm⁻ while the charge population decay accelerates from tens of nanoseconds to the picosecond range within the same fluence range.
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