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Unique Research for Developing a Full Factorial Design Evaluated Liquid Chromatography Technique for Estimating Budesonide and Formoterol Fumarate Dihydrate in the Presence of Specified and Degradation Impurities in Dry Powder Inhalation.
Biomed Chromatogr
February 2025
Department of Chemistry, GITAM School of Science, GITAM Deemed to Be University, Hyderabad, India.
A simple LC method has been developed and validated for estimating budesonide (epimer B + A) and formoterol fumarate dihydrate in dry powder inhalation. The development results of this study make it very significant. The degradation and process impurities in EP and ChP were identified in addition to budesonide and formoterol fumarate.
View Article and Find Full Text PDFAddition of long-acting beta-agonists to inhaled corticosteroids for asthma in preschool children: A systematic review.
Paediatr Respir Rev
October 2024
Department of Pediatric Pulmonology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:
Inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) are essential in asthma management, but the guidelines for treatment in preschool children remain heterogeneous worldwide. This systematic review evaluates the efficacy and safety of LABA + ICS therapy in asthmatic children under six years. We searched four databases, identifying six eligible studies (n = 1415 preschoolers), and in all the LABA used was salmeterol.
View Article and Find Full Text PDFThe change of FeNO is correlated with asthma control and lung function.
Heliyon
October 2024
Department of Pediatrics, the Eighth People's Hospital of Wuxi, Wuxi, China.
Article Synopsis
- The study aimed to examine how treatment with Budesonide/Formoterol Inhalation Powder Mist (B/FIPM) affected fractional exhaled nitric oxide (FeNO) levels in children with asthma and its impact on their prognosis and lung function.
- A total of 144 children were assessed, with their initial FeNO levels used to observe changes after treatment, and outcomes were evaluated after one year to determine if their asthma was well or partly controlled.
- Results showed that B/FIPM significantly decreased FeNO and eosinophil counts while improving lung function, with specific improvements noted based on the initial FeNO levels and treatment response.
Effects of inhaled beclometasone dipropionate/formoterol fumarate/glycopyrronium vs. beclometasone dipropionate/formoterol fumarate and placebo on lung hyperinflation and exercise endurance in chronic obstructive pulmonary disease: a randomised controlled trial.
Respir Res
October 2024
Global Clinical Development, Chiesi USA Inc, Cary, NC, USA.
Background: The single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) is available for maintenance therapy of chronic obstructive pulmonary disease (COPD). Cardinal features of COPD are lung hyperinflation and reduced exercise capacity. TRIFORCE aimed to evaluate the effect of BDP/FF/G on lung hyperinflation and exercise capacity in patients with COPD.
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