This study evaluated the effects of chronic stress and lithium treatments on oxidative stress parameters in hippocampus, hypothalamus, and frontal cortex. Adult male Wistar rats were divided into two groups: control and submitted to chronic variate stress, and subdivided into treated or not with LiCl. After 40 days, rats were killed, and lipoperoxidation, production free radicals, total antioxidant reactivity (TAR) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were evaluated. The results showed that stress increased lipoperoxidation and that lithium decreased free radicals production in hippocampus; both treatments increased TAR. In hypothalamus, lithium increased TAR and no effect was observed in the frontal cortex. Stress increased SOD activity in hippocampus; while lithium increased GPx in hippocampus and SOD in hypothalamus. We concluded that lithium presented antioxidant properties, but is not able to prevent oxidative damage induced by chronic variate stress.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11064-006-9139-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tyrosine Kinase Inhibitor Treatment Patterns in Patients With Chronic-Phase Chronic Myeloid Leukemia: A Single Center Data From China.
Clin Lymphoma Myeloma Leuk
December 2024
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China; Hematology Center, Peking University People's Hospital, Qingdao, China. Electronic address:
Aim: To describe tyrosine kinase inhibitor (TKI) treatment patterns and analyze co-variates of TKI switch for chronic myeloid leukemia (CML) patients in a center from China.
Methods: A retrospectively study was designed to analyze TKI switching patterns, reasons and associated covariates in patients with CP-CML.
Results: 1766 patients receiving initial imatinib (n = 1374), nilotinib (n = 254), dasatinib (n = 63) and flumatinib (n = 75) therapy were retrospectively interrogated.
Pain can't be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design.
BMC Med
December 2024
Department of Biomedical Engineering, Montreal Neurological Institute, McGill University and Mila - Quebec AI Institute, Montreal, Canada.
Background: Pain is a complex problem that is triaged, diagnosed, treated, and billed based on which body part is painful, almost without exception. While the "body part framework" guides the organization and treatment of individual patients' pain conditions, it remains unclear how to best conceptualize, study, and treat pain conditions at the population level. Here, we investigate (1) how the body part framework agrees with population-level, biologically derived pain profiles; (2) how do data-derived pain profiles interface with other symptom domains from a whole-body perspective; and (3) whether biologically derived pain profiles capture clinically salient differences in medical history.
View Article and Find Full Text PDFThe Possible Association of Burnout and Neuropathic Low Back Pain Among Hungarian Postal Workers: A Cross-Sectional Study.
J Multidiscip Healthc
November 2024
Centre for Occupational Medicine, Medical School, University of Pécs, Pecs, 7624, Hungary.
Objective: Burnout is an increasingly prevalent phenomenon, which can be associated with a wide range of mental and physical illnesses. There is also a possible connection between burnout and neuropathic low back pain, but the association is poorly studied.
Methods: The aim of our cross-sectional study was to analyze the prevalence and risk factors of chronic neuropathic low back pain taking many co-variates into account, such as burnout and its main determinants among postal workers.
Caregiving, caring intensity, and allostatic load: A comparison of caring to others inside and outside the home.
J Psychosom Res
December 2024
Department of Psychology, Centre for Social Issues Research, Study of Anxiety, Stress and Health Laboratory, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Castletroy, Limerick, Ireland.
Objective: Caregiving to a sick or disabled relative is a key chronic stress model in health psychology. However, caregiving is not uniformly stressful, and this study tested whether caregiving effects on life satisfaction and allostatic load varies by caring intensity, i.e.
View Article and Find Full Text PDFExploring low- and high-order functional connectivity in chronic ankle instability through resting-state fMRI.
Med Phys
January 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Background: The functional connectivity (FC) has emerged as a valuable tool for comprehending the cerebral operational mechanism. Understanding the FC changes in patients with chronic ankle instability (CAI) helps reveal the underlying central nervous system mechanisms of the disease and provides clues for developing personalized treatment plans.
Objectives: To explore differences between low- and high-order FC in patients with CAI and healthy controls, as well as the correlation among the feature connections and clinical data.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!