Objective: To investigated the effect of chemoattractant of rhTNF-alpha on TB-LCL. Set up a model for study the interaction between cytokine and B cells.
Method: PTC were transfected with Epstein Barr virus, to get tonsil B lymphoblastic cell line(TB-LCL).
Result: It was found rhTNF-alpha can chemotactic TB-LCL, in a dose-dependent manner and this chemotactic effect can be blocked by the neutralizing antibody E6 against TNF.
Conclusion: This is an useful model in study the interfere between chemokine and immunocyte.
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