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Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus.
World J Exp Med
December 2024
Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10430, Indonesia.
Hepatitis B virus (HBV) infection is a major public health burden. In HBV endemic regions, high prevalence is also correlated with the infections acquired in infancy through perinatal transmission or early childhood exposure to HBV, the so-called mother-to-child transmission (MTCT). Children who are infected with HBV at a young age are at higher risk of developing chronic HBV infection than those infected as adults, which may lead to worse clinical outcome.
View Article and Find Full Text PDF[Analysis on the status quo of awareness of knowledge about hepatitis C prevention and treatment and its influencing factors among people aged 15-65 years in Henan Province, 2021].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Office of Preventive Medicine Association, Henan Provincial Center for Disease Control and Prevention, Zhengzhou450016, China.
From June to September 2021, residents aged 15-65 years from 18 provincial cities and 10 directly administered counties (cities) in Henan Province were collected for a questionnaire survey, so as to understand the status quo of the knowledge and related influencing factors of hepatitis C prevention and treatment. Among 11 627 subjects, the adjusted awareness rate of knowledge about hepatitis C prevention and treatment was 59.2% (95%: 58.
View Article and Find Full Text PDFtRNA-Ser-UGA efficiently promotes the rapid release of duck hepatitis A virus from infected enterocytes and its remote dissemination to hepatocytes.
Poult Sci
December 2024
Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Sichuan Agricultural University, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, China; Institute of Veterinary Medicine and Immunology, College of Veterinary Medicine, Sichuan Agricultural University, China. Electronic address:
Enterocytes are a necessary portal for fecal-oral transmission of viruses, including duck hepatitis A virus (DHAV), that act on the absorption of amino acids (AAs). We note that the rapid death of ducklings caused by DHAV is likely due to its rapid release from enterocytes. However, the underlying mechanism driving the release of DHAV remains poorly understood.
View Article and Find Full Text PDFA Health Systems Strengthening Approach to Address the High Burden of Hepatitis C in Pakistan.
J Viral Hepat
January 2025
School of Health Sciences, The University of Manchester, Manchester, UK.
Hepatitis C virus infection is a serious liver disease that can progress to cirrhosis and, in chronic cases, lead to liver cancer or liver failure. Pakistan has the second highest burden of HCV in the world, a rising number of liver cancer cases and a unique pattern of healthcare-associated HCV transmission. Unfortunately, the country is not on track to meet the WHO's target of complete elimination of HCV by 2030.
View Article and Find Full Text PDFHepatitis B Care and Treatment in Zanzibar, Tanzania: A Demonstration Project Following 2015 WHO Treatment Guidelines, 2017-2021.
J Viral Hepat
January 2025
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Zanzibar, a low-resource semiautonomous region of Tanzania, has an estimated prevalence of hepatitis B virus (HBV) infections of 3.6%. To assess the feasibility of care and treatment, a 5-year hepatitis B demonstration project was implemented in Zanzibar during January 2017-December 2021, following the 2015 WHO HBV care and treatment guidelines.
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