AI Article Synopsis
- The study involved 22 adults with moderate-to-severe asthma who were randomly assigned to two groups, alternating between fluticasone dry powder inhaler (DPI) and hydrofluoroalkane-beclometasone dipropionate (HFA-BDP) over 18 weeks.
- While both treatments showed no significant differences in beta2-agonist use and symptom scores, HFA-BDP resulted in significantly better pulmonary function measurements compared to fluticasone DPI, with improved morning peak expiratory flow (PEF) and forced expiratory volume (FEV1.0).
- Additionally, HFA-BDP was associated with lower levels of inflammatory markers in sputum and expired gas, suggesting it may be more
Article Abstract
In this randomized crossover study, 22 adult patients with moderate-to-severe persistent bronchial asthma were assigned to one of two groups. Patients in group 1 were administered fluticasone dry powder inhaler (DPI) for 8 weeks followed by a 2-week washout period, then hydrofluoroalkane-beclometasone dipropionate (HFA-BDP) for 8 weeks. After a further 2-week washout, they were again administered fluticasone DPI for 8 weeks. Patients in group 2 were assigned HFA-BDP followed by fluticasone PII and finally HFA-BDP over the same time periods. In both groups, no significant difference was observed in use of beta2-agonists and symptom score between the treatment periods; however, markers of pulmonary function were significantly higher when on HFA-BDP versus fluticasone DPI. Significant increases of morning peak expiratory flow (PEF) (p < 0.01), forced expiratory volume in 1 second (FEV1.0) (p < 0.01), V50 (p < 0.05), and V25 (p < 0.01) were observed at 18 weeks in group 1, whereas there were significant decreases of V50 (p < 0.05) at 18 weeks in group 2. No significant difference was noted in circulating eosinophil count and serum ECP between the 2 treatments; however, ECP in induced sputum and nitric oxide in expired gas were significantly lower (p < 0.05 and < 0.01, respectively) when on HFA-BDP versus fluticasone DPI. HFA-BDP might be delivered to small airways more effectively than fluticasone DPI.
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| http://dx.doi.org/10.1080/02770900600758465 | DOI Listing |
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