[Expression of p75 and hepatic stellate cell apoptosis during spontaneous resolution of rat liver fibrosis].

Zhonghua Gan Zang Bing Za Zhi

Department of Gastroenterology, Nineth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.

Published: August 2006

Download full-text PDF

Source

Publication Analysis

Top Keywords

[expression p75
4
p75 hepatic
4
hepatic stellate
4
stellate cell
4
cell apoptosis
4
apoptosis spontaneous
4
spontaneous resolution
4
resolution rat
4
rat liver
4
liver fibrosis]
4

Similar Publications

Olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs) differentiated towards Schwann-like have plasticity properties. These cells express the Glial fibrillary acidic protein (GFAP), a type of cytoskeletal protein that significantly regulates many cellular functions, including those that promote cellular plasticity needed for regeneration. However, the expression of GFAP isoforms (α, β, and δ) in these cells has not been characterized.

View Article and Find Full Text PDF

Background And Aim: Human dental pulp stem cells (hDPSCs) constitute a promising alternative for central nervous system (CNS) cell therapy. Unlike other human stem cells, hDPSCs can be differentiated, without genetic modification, to neural cells that secrete neuroprotective factors. However, a better understanding of their real capacity to give rise to functional neurons and integrate into synaptic networks is still needed.

View Article and Find Full Text PDF

The location of a patient's colorectal cancer (CRC) influences their outcome but inherited factors may also be involved. We studied 1899 patients with advanced CRC (514 had proximal colonic, 493 distal colonic and 892 rectal tumours) and carried out genome-wide association studies for survival. Single nucleotide polymorphisms (SNPs) suggestive of association (P < 1.

View Article and Find Full Text PDF

LEDGF/p75 promotes transcriptional pausing through preventing SPT5 phosphorylation.

Sci Adv

January 2025

Department of Hematology, Zhongda Hospital, Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.

SPT5 exhibits versatile functions in RNA Pol II promoter proximal pausing, pause release, and elongation in metazoans. However, the mechanism underlying the functional switch of SPT5 during early elongation has not been fully understood. Here, we report that the phosphorylation site-rich domain (PRD)/CTR1 and the prion-like domain (PLD)/CTR2, which are situated adjacent to each other within the C-terminal repeat (CTR) in SPT5, play pivotal roles in Pol II pausing and elongation, respectively.

View Article and Find Full Text PDF

Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75 receptor plays a key role in this process localizing asymmetrically in one of the differentiating neurites and specifying its axonal identity in response to neurotrophins. During axonal specification, p75 levels are transiently modulated, yet the molecular mechanisms underlying this process are not known.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!