Background: Gestational trophoblastic disease (GTD) after fertility therapy seems to be a rare complication despite the widespread use of these treatments. Despite embryos derived from normally fertilized oocytes were transferred, molar pregnancies still occurring.
Cases: Two patients underwent first cycle of in vitro fertilization (IVF) for management of infertility related to tubal obstruction. GTD was diagnosed by histopathology.
Conclusion: It is unlikely that this complication is directly related to the technique of IVF itself but rather the characteristics of women and the partner attending for assisted conception make them more at risk of molar pregnancies. The management includes prompt curettage and regular follow-up.
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