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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment.
Front Endocrinol (Lausanne)
January 2025
Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Background: Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.
Methods: The publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively.
Multidimensional structural analyses revealed a correlation between thalamic atrophy and white matter degeneration in idiopathic dystonia.
Brain Commun
January 2025
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou 510080, China.
Although aberrant changes in grey and white matter are core features of idiopathic dystonia, few studies have explored the correlation between grey and white matter changes in this disease. This study aimed to investigate the coupling correlation between morphological and microstructural alterations in patients with idiopathic dystonia. Structural T1 imaging and diffusion tensor imaging were performed on a relatively large cohort of patients.
View Article and Find Full Text PDFAssessment of Accuracy of Spatial Object Localization by Means of Mono and Stereo Modes of Visual-to-Auditory Sensory Substitution in People with Visual Impairments (a Pilot Study).
Sovrem Tekhnologii Med
January 2025
PhD, Leading Researcher; Institute of Industrial Ecology of the Ural Branch of the Russian Academy of Sciences, 20 S. Kovalevskoy St., Ekaterinburg, 620990, Russia.
Unlabelled: is to assess the accuracy of spatial object localization in mono and stereo modes of visual-to-auditory sensory substitution by means of the developed system tested on persons with normal or corrected-to-normal vision.
Materials And Methods: A prototype of a visual-to-auditory sensory substitution device based on a video camera with two lenses was prepared. Software to convert the signal from a video camera into an audio signal in mono and stereo modes was developed.
Enhancing transcranial ultrasound stimulation planning with MRI-derived skull masks: a comparative analysis with CT-based processing.
J Neural Eng
January 2025
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Transcranial ultrasound stimulation (TUS) presents challenges in ultrasound wave transmission through the skull, affecting study outcomes due to aberration and attenuation. While planning strategies incorporating 3D computed tomography (CT) scans help mitigate these issues, they expose participants to radiation, which can raise ethical concerns. A solution involves generating skull masks from participants' anatomical magnetic resonance imaging (MRI).
View Article and Find Full Text PDFThe Shab family potassium channels are highly enriched at the presynaptic terminals of human neurons.
J Biol Chem
January 2025
Biochemistry & Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA; Molecular, Cellular & Integrated Neurosciences, Colorado State University, Fort Collins, CO 80523, USA; Cell & Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:
The Shab family voltage-gated K channels (i.e., Kv2.
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