AI Article Synopsis
- PCP (Phencyclidine) was used in a study with male rats to simulate cognitive dysfunctions similar to those found in schizophrenia, specifically in learning and memory, utilizing the Morris water maze for evaluation.
- The study distinguished between working memory and reference memory using specific experimental protocols, administering PCP and a nitric oxide synthase inhibitor, L-NAME, to assess their effects.
- Findings revealed that PCP impaired both types of memory acquisition, but pre-treatment with L-NAME reversed these impairments without significantly affecting memory retention on its own.
Article Abstract
Phencyclidine (PCP), a non-competitive NMDA receptor antagonist, was used to model schizophrenia-like cognitive dysfunctions of learning and memory in rats using the Morris water maze model for spatial memory. A protocol introduced by Baldi and co-workers was used to distinguish working memory from reference memory. Male Sprague-Dawley rats were administered PCP (2.0 mg/kg) before the first swimming trial on each of five spatial memory acquisition days, either alone or after pre-treatment with the nitric oxide synthase inhibitor, L-NAME (10 mg/kg). Probe tests for memory were conducted before and after each acquisition session. The results showed that PCP disrupted the acquisition of both working and reference memory. Pre-treatment with L-NAME reversed both these effects of PCP. L-NAME treatment by itself did not significantly alter either acquisition or retention of spatial memory.
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| http://dx.doi.org/10.1016/j.bbr.2006.07.003 | DOI Listing |
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