Purpose: Investigate whether the use of non coplanar fields and intensity modulated radiation therapy (IMRT) reduces the dose to the heart, in irradiation of middle and lower lung tumors.
Materials And Methods: Four plans are compared on 10 CT scans: (1) a reference plan, corresponding to coplanar plan of 3D conformal radiotherapy (3DCRT); (2) a 3DCRT(noncopl) plan, differing from reference plan by the change of one field in non coplanar fields; (3) an IMRT(copl) plan optimized on the same coplanar plan as reference plan; and (4) an IMRT(noncopl) plan optimized on the same non coplanar beams as 3DCRT(noncopl) plan. The equivalent uniform dose (EUD) for PTV was 74 Gy in 37 fractions.
Results: In all plans, the 95% isodose surface covers at least 99% of the PTV with very similar conformity index values. A significant reduction in EUD, V30, V40 and V50 is observed for heart when either non coplanar fields or IMRT is used. IMRT also reduces the lung NTCP, V5, V13, V20 and V30 values and esophagus NTCP.
Conclusion: Both the use of non coplanar fields and IMRT dramatically reduces the dose received by the heart. The largest benefit is seen when the two techniques are combined.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.radonc.2006.07.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A High-Repeatability Three-Dimensional Force Tactile Sensing System for Robotic Dexterous Grasping and Object Recognition.
Micromachines (Basel)
December 2024
School of Aerospace Science and Technology, Xidian University, Xi'an 710071, China.
Robotic devices with integrated tactile sensors can accurately perceive the contact force, pressure, sliding, and other tactile information, and they have been widely used in various fields, including human-robot interaction, dexterous manipulation, and object recognition. To address the challenges associated with the initial value drift, and to improve the durability and accuracy of the tactile detection for a robotic dexterous hand, in this study, a flexible tactile sensor is designed with high repeatability by introducing a supporting layer for pre-separation. The proposed tactile sensor has a detection range of 0-5 N with a resolution of 0.
View Article and Find Full Text PDFCombined Dielectric-Optical Characterization of Single Cells Using Dielectrophoresis-Imaging Flow Cytometry.
Biosensors (Basel)
November 2024
Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
In this paper, we present a microfluidic flow cytometer for simultaneous imaging and dielectric characterization of individual biological cells within a flow. Utilizing a combination of dielectrophoresis (DEP) and high-speed imaging, this system offers a dual-modality approach to analyze both cell morphology and dielectric properties, enhancing the ability to analyze, characterize, and discriminate cells in a heterogeneous population. A high-speed camera is used to capture images of and track multiple cells in real-time as they flow through a microfluidic channel.
View Article and Find Full Text PDFIntroducing Noncovalent Interactions in Conjugated Polymers to Enhance Backbone Coplanarity and Aggregation at the Interface to Improve Carrier Mobility.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
In organic field-effect transistors (OFETs), the high carrier mobility of conjugated polymers (CPs) is significantly influenced by the maintenance of excellent coplanarity and aggregation, especially at the interface between the organic semiconductor and dielectric layer. Unfortunately, CPs typically exhibit poor coplanarity due to the single bond rotations between donor and acceptor units. Furthermore, there is relatively little research on the coplanarity of CPs at the interface.
View Article and Find Full Text PDFSimple Models of Directly Measured Energy Landscapes for Different Shaped Particles in Nonuniform AC Electric Fields.
Langmuir
November 2024
Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Article Synopsis
- The study investigates how colloidal particles of various shapes, like disks and rectangles, behave in nonuniform AC electric fields, focusing on their potential energy landscapes.
- Researchers used optical microscopy to track the positions and orientations of single particles and applied Boltzmann inversions to obtain energy landscapes for these shapes.
- A new model was developed that explains the measured energy landscapes for superelliptical prism-shaped particles and can also accurately describe the behavior of spherical and ellipsoidal particles.
Suppression of magnetic vortex losses in submicron NbN coplanar waveguide resonators.
Sci Rep
November 2024
Institute of Superconductivity and Institute of Nanotechnology, Department of Physics, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
We present a method for improving the performance of microwave coplanar resonators in magnetic fields, by using narrow superconducting strips of width close to the London penetration depth. In a range of low fields, the narrow strips inhibit the presence of magnetic vortices, thus preventing the generation of losses caused by their motion, leading to enhanced resistance to magnetic fields. Our method provides a more straightforward solution compared to previously proposed techniques designed to restrict vortex motion, holding potential for the development of improved devices based on microwave resonators.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!