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| http://dx.doi.org/10.1186/cc5000 | DOI Listing |
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Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism.
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, Chengdu Second People's Hospital, Chengdu, China.
A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone tests, leading to a diagnosis of primary bilateral macronodular adrenal hyperplasia. Concurrently, elevated blood calcium and parathyroid hormone levels, along with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) imaging revealing increased 99mTc-MIBI uptake in the right inferior parathyroid gland, suggest the consideration of primary hyperparathyroidism.
View Article and Find Full Text PDFUltrasonographic adrenal gland changes in dogs with Cushing's syndrome with a low-dose dexamethasone suppression test result consistent with partial suppression or escape pattern.
Front Vet Sci
December 2024
Clinic of Small Animal Medicine, LMU Munich, Munich, Germany.
Background: Cushing's syndrome (CS) in dogs is mainly caused by pituitary-dependent (PDH) or adrenal-dependent (ADH) hypercortisolism. Result of the low-dose-dexamethasone suppression test (LDDST) with partial suppression (PSP) or escape pattern (EP) are indicative of PDH. No data concerning the ultrasonographic characteristics of the adrenal glands from dogs with these patterns exists.
View Article and Find Full Text PDFIs there still a place for etomidate in the management of Cushing's syndrome? The experience of a single center of low-dose etomidate and combined etomidate-osilodrostat treatment in severe hypercortisolemia.
Endocrine
December 2024
Department of Internal Medicine, Endocrinology and Diabetes, Medical University of Warsaw, Warsaw, Poland.
Purpose: Severe Cushing's syndrome (SCS) is a life-threatening endocrine condition that requires prompt medical intervention. Intravenous etomidate infusion is considered to be the most effective in rapid cortisol overproduction inhibition. This single-center retrospective study aimed to present the safety and effectiveness of intravenous, low-dose, lipid-formulated etomidate infusion in patients with SCS.
View Article and Find Full Text PDFAdrenal Cortical Carcinoma Presenting as CSCR.
Retin Cases Brief Rep
November 2024
Northern California Kaiser Permanente, Roseville, CA, USA.
Purpose: We describe a case of bilateral chronic central serous chorioretinopathy (CSCR) secondary to adrenal cortical carcinoma.
Methods: Case report of a 70-year-old Hispanic man presenting with bilateral multifocal CSCR.
Results: Clinical findings of bilateral chronic CSCR along with 160 µm of subretinal fluid (SRF) and choroidal thickness greater than 400 µm without enhanced depth optical coherence tomography was noted in a patient presenting with distortion in vision in both eyes and weight gain of 15 pounds, weakness, and fatigue starting 8 months prior.
Characterization of a novel variant in the NR3C1 gene: differentiating glucocorticoid resistance from Cushing Syndrome.
J Clin Endocrinol Metab
November 2024
Institute of Endocrinology, Diabetes, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Article Synopsis
- Primary generalized glucocorticoid resistance syndrome (GGRS) is a rare condition linked to a mutation in the NR3C1 gene, specifically a missense variant affecting the Glucocorticoid Receptor's DNA Binding Domain.
- A case study detailed a 59-year-old man with high cortisol levels and a misdiagnosis of Cushing disease, ultimately leading to a correct diagnosis of GGRS at age 68.
- Functional tests on the identified gene variant indicated it had significantly reduced transcriptional activity, emphasizing the need for increased awareness of GGRS to prevent misdiagnosis and harmful treatments.
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