Success of the Medicare prescription drug benefit depends on private organizations offering beneficiaries appropriate access to medications while controlling costs. There is limited guidance, however, as to what constitutes best practice in benefit and formulary design. This issue brief examines Medicare stand-alone prescription drug plans in the four most populous Medicare states-California, Florida, New York, and Texas. While there are similar offerings in all four states, there is wide variation in the amount of drugs covered, how drugs are accessed by beneficiaries, and prior authorization requirements. Plans with lower premiums are more likely to have additional formulary tiers and no coverage in the "doughnut hole"-the gap faced by many beneficiaries between $2,250 and $5,100 in costs. Given the many choices facing beneficiaries, the Centers for Medicare and Medicaid Services should monitor experiences to determine whether plans are meeting the needs of Medicare beneficiaries, particularly the frail and disabled.
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J Clin Oncol
January 2025
INSERM, IMRBU955, Univ Paris Est Créteil, Créteil, France.
Purpose: Establishing an accurate prognosis remains challenging in older patients with cancer because of the population's heterogeneity and the current predictive models' reduced ability to capture the complex interactions between oncologic and geriatric predictors. We aim to develop and externally validate a new predictive score (the Geriatric Cancer Scoring System [GCSS]) to refine individualized prognosis for older patients with cancer during the first year after a geriatric assessment (GA).
Materials And Methods: Data were collected from two French prospective multicenter cohorts of patients with cancer 70 years and older, referred for GA: ELCAPA (training set January 2007-March 2016) and ONCODAGE (validation set August 2008-March 2010).
JAMA Netw Open
January 2025
San Francisco Department of Public Health, San Francisco, California.
Importance: The rise of high-potency opioids such as fentanyl makes buprenorphine initiation challenging due to the risks of precipitated withdrawal, prompting the exploration of strategies, such as low-dose initiation (LDI) of buprenorphine. However, no comparative studies on LDI outcomes exist.
Objective: To evaluate outpatient outcomes associated with 2 LDI protocols of buprenorphine among individuals with opioid use disorder (OUD) using fentanyl.
Rev Med Chil
November 2024
Núcleo de Humanidades y Ciencias Sociales, Universidad del Desarrollo, Santiago, Chile.
Unlabelled: Alcohol consumption by older adults has been called the "silent epidemic." An aging population and high levels of alcohol consumption increase the future challenge for epidemiology and public health. In addition, the misuse of prescription drugs is a growing public health problem associated with increased hospitalizations and health complications in older adults.
View Article and Find Full Text PDFJ Imaging
January 2025
School of Information Technology, Sripatum University, Bangkok 10900, Thailand.
This study introduces a novel AI-driven approach to support elderly patients in Thailand with medication management, focusing on accurate drug label interpretation. Two model architectures were explored: a Two-Stage Optical Character Recognition (OCR) and Large Language Model (LLM) pipeline combining EasyOCR with Qwen2-72b-instruct and a Uni-Stage Visual Question Answering (VQA) model using Qwen2-72b-VL. Both models operated in a zero-shot capacity, utilizing Retrieval-Augmented Generation (RAG) with DrugBank references to ensure contextual relevance and accuracy.
View Article and Find Full Text PDFClin Pract
December 2024
Department of Gynaecology and Obstetrics, University Hospital Ulm, Prittwitzstr. 43, 89075 Ulm, Germany.
The survival in early breast cancer (BC) has been significantly improved thanks to numerous new drugs. Nevertheless, the information about the need for systemic therapy, especially chemotherapy, represents an additional stress factor for patients. A common coping strategy is searching for further information, traditionally via search engines or websites, but artificial intelligence (AI) is also increasingly being used.
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