AI Article Synopsis
- A 56-year-old man experienced 6 months of unusual behavior changes and a lack of interest in his family, prompting a hospital visit despite unremarkable medical exams.
- Extensive investigations, including brain scans and antibody testing, were conducted to diagnose his condition.
- The diagnosis revealed voltage-gated potassium channel antibody-related limbic encephalitis, leading to treatment with antiepileptic drugs, immunomodulatory therapy, oral steroids, and plasma exchange.
Article Abstract
Background: A 56-year-old man presented to hospital with a 6-month history of recurrent episodes of altered behavior and 'odd' episodes. He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing.
Investigations: Brain MRI scan, 24-h electroencephalogram, serum and cerebrospinal fluid testing for voltage-gated potassium channel antibodies, blood screening for tumors, CT scans of the chest, abdomen and pelvis, whole-body PET scan, neuropsychological examination, brain 18F-fluorodeoxyglucose-PET scan.
Diagnosis: Voltage-gated potassium channel antibody-related limbic encephalitis.
Management: Antiepileptic drugs, immunomodulatory therapy, oral steroids, plasma exchange.
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| http://dx.doi.org/10.1038/ncpneuro0194 | DOI Listing |
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