Mutations in neuronal nicotinic acetylcholine receptors have been demonstrated in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). The beneficial effect of nicotine administration was previously reported in one single case. We investigated the influence of the tobacco habits of 22 subjects from two pedigrees with alpha4 mutations (776ins3 and S248F). Subjects were interviewed with respect to pattern of nicotine intake and seizures. Seizure freedom was significantly associated with tobacco use (P=0.024). All seven nonsmokers with manifest ADNFLE had persistent seizures. Seizure fluctuations, including long remissions, corresponded to changes in tobacco habits in several patients. One patient who recently had begun treatment with transdermal nicotine experienced improvement. We conclude that tobacco appears to be an environmental factor that influences seizure susceptibility in ADNFLE. Inactivation by desensitization of the mutant receptors by nicotine may explain the beneficial effect. The efficacy and safety of transdermal nicotine in ADNFLE should be further explored.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yebeh.2006.07.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of iron deficiency anemia with dental caries in the permanent first molars of children aged 7-12 years in Karachi, Sindh, Pakistan: protocol for an analytical cross-sectional study.
BMJ Open
January 2025
Population & Reproductive Health Section, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
Introduction: Iron deficiency anaemia (IDA) and dental caries are prevalent diseases among Pakistani children. Limited research has been done to explore their association with permanent teeth. Given the caries susceptibility of permanent first molars and their role in the development of ideal occlusion, this study aimed to estimate caries frequency in these molars and assess its association with IDA in 7-12 year-old children.
View Article and Find Full Text PDFPerceptions and Experiences of Primary Care Providers on Their Role in Tobacco Treatment Delivery Based on Their Smoking Status: A Qualitative Study.
Healthcare (Basel)
December 2024
Laboratory of Primary Health Care, General Practice and Health Services Research, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Introduction: Despite the well-documented benefits of smoking cessation interventions, the implementation and success of these programs in primary care settings often encounter significant barriers. A primary care provider's personal smoking status has been identified as a potential barrier to tobacco treatment delivery. The aim of this qualitative study is to explore the experiences and perspectives of primary care providers regarding their role in delivering smoking cessation interventions to patients based on their personal smoking status.
View Article and Find Full Text PDFAssociation of socio-demographic characteristics, comorbidities, lifestyle habits, and saliva parameters with dental caries in adults with obesity.
Acta Odontol Scand
January 2025
CHU de Bordeaux, Pôle de Médecine et Chirurgie Bucco-Dentaire, F-33000 Bordeaux, France; Univ. Bordeaux, Oral Health Department, F-33000 Bordeaux, France.
Objective: To describe the oral health status of patients with obesity and to explore the socio-demographic characteristics, comorbidities, lifestyle habits (tobacco, alcohol, sweet/acidic diet), and saliva parameters most associated with the dental caries experience. Material and methods: We conducted a cross-sectional analysis of 204 patients' data with obesity attending a therapeutic education programme. Caries experience (number of decayed, missing, and filled teeth [DMFT]), periodontal status, oral hygiene, occlusal tooth wear, masticatory inefficiency, and saliva parameters were recorded.
View Article and Find Full Text PDFInvestigating Oral Cancer Awareness Among Medical and Dental Students: A Cross-Sectional Study in the South Canara Region of India.
ScientificWorldJournal
January 2025
Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Oral cancer is responsible for increased mortality, especially in the Indian subcontinent. Habits like smoking and tobacco chewing are among the most common causes of oral cancer. Previously, these habits were seen mainly in the elderly; however, the trends have seemed to increase in the younger generation.
View Article and Find Full Text PDFChanging Patterns of Lung Cancer Mortality in Andalusia: Insights From Age-period-cohort Analysis and Historical Smoking Trends.
Open Respir Arch
November 2024
Unit of Public Health, Prevention and Health Promotion, South Seville Health Management Area, Seville, Spain.
Introduction: Lung cancer remains one of the leading causes of cancer death worldwide. This study examines lung cancer mortality trends in Andalusia, Spain, from 2003 to 2022, focusing on gender differences and the influence of age, period and cohort effects.
Material And Methods: This longitudinal ecological study analyzed lung cancer mortality data in Andalusia from 2003 to 2022, using age-period-cohort (A-P-C) and joinpoint regression models.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!