AI Article Synopsis
- The study explores the combined effects of L-carnitine (LCLT) and DHEAS supplementation on blood cell counts in aging male rats, as previous research is limited on their interactive benefits.
- Over a 3-month period, rats receiving both LCLT and DHEAS showed a decrease in red blood cells (RBCs) and an increase in platelets, indicating a potential improvement in blood chemistry.
- Additionally, DHEAS alone caused a shift in white blood cell types, highlighting the distinct yet complementary impact of each supplement on immune cell dynamics.
Article Abstract
Supplementation with either L-carnitine or DHEAS was separately suggested to counteract age-related declines. However, little is known about any interactive effects of these substances, independently promoting mitochondrial energy metabolism, in older individuals. We thus studied the effects of 3 months of daily oral combined supplementation with LCLT and DHEAS on red (RBCs) and white blood cells (WBCs) in male Sprague-Dawley rats by determining RBC and WBC counts, lymphocyte proliferation and interleukin-2 (IL-2) synthesis in spleen lymphocytes after Concanavalin A (ConA) stimulation. Supplementation with LCLT in addition to DHEAS decreased RBCs and increased platelets in the blood of 25-month-old Sprague-Dawley rats, whereas supplementation with DHEAS alone shifted the balance from segmented neutrophile granulocytes to large lymphocytes in differential WBC counts. Based on these results, interactive effects of supplementation with L-carnitine and DHEAS on RBCs and platelets are suggested.
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| http://dx.doi.org/10.1016/j.archger.2006.07.003 | DOI Listing |
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