Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives.

J Org Chem

Global Innovative R & D, Teva Pharmaceutical Industries Ltd., Netanya 42504, Israel.

Published: September 2006

5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.

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Source
http://dx.doi.org/10.1021/jo0609881DOI Listing

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