The diagnosis of granular acute lymphoblastic leukemia (ALL) can be problematic as the cytoplasmic granules found in many blast cells may mimic those seen in acute myelogenous leukemia (AML). This rare variant of B-cell ALL is more commonly diagnosed in children, but may occur in adults. We report a case of granular B-ALL in a 56-year-old female and review the literature.
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http://dx.doi.org/10.1097/01.smj.0000231247.33762.f3 | DOI Listing |
Biochem Biophys Res Commun
December 2024
Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, South Korea. Electronic address:
Radiation therapy is crucial for cancer treatment, but it often causes tissue damage. The kidney, which is sensitive to radiation, is under-researched in this context. This study aimed to develop a mouse model for radiation-induced acute kidney injury (AKI) using a small animal radiation research platform (SARRP) to mimic clinical radiation conditions.
View Article and Find Full Text PDFAm J Health Syst Pharm
December 2024
The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFJ Med Econ
December 2024
Pfizer Inc., Tadworth, Surrey, United Kingdom.
Aims: Nirmatrelvir/ritonavir (NMV/r) is an orally administered antiviral indicated for the outpatient treatment of adult patients with mild-to-moderate COVID-19 at high risk for disease progression to severe illness. We estimated the cost-effectiveness of NMV/r versus best supportive care for 54 patient cohorts, specified according to age, vaccination status and comorbidity burden.
Materials And Methods: A previously published and validated cost-effectiveness model was utilized and adapted to the Swedish setting.
J Trauma Acute Care Surg
December 2024
From the Division of Trauma, Burn, and Surgical Critical Care, Department of Surgery (M.C.-A., C.B.S., J.C.E., C.W., S.N., R.A., Z.C., A.S., J.M.H.), Brigham and Women's Hospital, Harvard Medical School; Center for Surgery and Public Health, Department of Surgery (M.C.-A., C.K.Z., M.J., Z.C., A.S., J.M.H.), Brigham and Women's Hospital, Harvard Medical School; Harvard T. H. Chan School of Public Health (M.C.-A., C.K.Z., M.J., Z.C., A.S., J.M.H.), Boston, Massachusetts; and Department of Surgery (C.K.Z.), Duke University Medical Center, Durham, North Carolina.
Leuk Res Rep
November 2024
Hematology Laboratory, Central laboratory, Mohammed VI University Hospital, Oujda, Morocco.
Introduction: Acute promyelocytic leukemia (AML-M3), classified as acute Myeloid leukemia with PML RARA according to the 5th edition of the World Health Organization classification of haematolymphoid tumors 2022 [1], is marked by abnormal promyelocyte proliferation and is known for high risks of bleeding and thromboembolic complications. We present a case where lower limb ischemia revealed this leukemia in a child.
Case Report: An 11-year-old with minor ankle trauma developed severe lower limb ischemia, leading to the discovery of subtotal femoral artery thrombosis.
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