Despite the advances in laser treatment of port wine stains (PWS), re-emergence of these lesions still occurs. We carried out a retrospective audit of all children that received laser treatment of PWS between 1997 and 2000 using the flashlamp-pumped dye laser with a 585-nm wavelength. Out of 110 patients treated, 15 re-emerged. The age ranged between 7 months and 15 years. Fourteen had lesions in the head and neck. Before re-emergence, a child had, on average, 6.2 sessions every 4.8 months. Lesions re-emerged on average 31.1 months following discontinuation of treatment. The natural history of an untreated PWS is to darken as the vessels become more ectatic. Therefore, it is not surprising that any residual vessels not affected by laser will continue to progress in this way, causing re-emergence of the lesion. Perhaps we should expect most or all of treated PWS to eventually re-emerge.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/01.sap.0000221620.83178.fc | DOI Listing |
Front Pediatr
January 2025
Department of Dermatology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, China.
Objective: The purpose of this study is to explore the efficacy and safety of hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) in treating children with port-wine stains (PWS).
Method: Literature related to the topic was searched in PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, and China Science Technology Journal Database online databases. The quality of the literature was evaluated using the Effective Public Health Practice Project.
Biomed Microdevices
January 2025
Institute of Industrial Science, The University of Tokyo, Meguro-Ku, 153-8505, Tokyo, Japan.
Recently, photodynamic therapy (PDT) which involves a photosensitizer (PS), a special drug activated by light, and light irradiation has been widely used in treating various skin diseases such as port-wine stain as well as cancers such as melanoma and non-melanoma skin cancers. PDT comprises two general steps: the introduction of PS into the body or a specific spot to be treated, and the irradiation process using a light source with a specific wavelength to excite the PS. Although PDT is gaining great attention owing to its potential as a targeted approach in the treatment of skin cancers, several limitations still exist for practical use.
View Article and Find Full Text PDFAME Case Rep
December 2024
Department of Dermatology, King Fahad Medical City, Riyadh, Saudi Arabia.
Background: Phakomatosis pigmentovascularis (PPV) is a rare congenital cutaneous syndrome characterized by capillary malformation and extensive dermal melanosis. The complexity of PPV is reflected in its evolving classification systems. Systemic manifestations encompass ocular, neurological, vascular, musculoskeletal, and renal involvement.
View Article and Find Full Text PDFBMJ Open
December 2024
INSERM UMR1231 Génétique des Anomalies du Développement (GAD), Université de Bourgogne, Dijon, France.
Introduction: The megalencephaly capillary malformation polymicrogyria (MCAP syndrome) results from mosaic gain-of-function variants. The main clinical features are macrocephaly, somatic overgrowth, neurodevelopmental delay and brain anomalies. Alpelisib (Vijoice) is a recently FDA-approved PI3Kα-specific inhibitor for patients with PIK3CA-related overgrowth spectrum (PROS).
View Article and Find Full Text PDFJ Am Acad Dermatol
December 2024
Departments of Dermatology, Otolaryngology, Surgery, and Medical Social Sciences, Northwestern Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!