Background: Plasma insulin-like growth factor 1 (IGF-1) and the response of growth hormone (GH) to oral glucose are frequently used in the evaluation of patients suspected of acromegaly. Because of the implementation of new assay methodology for GH and IGF-1, we have established the reference values for these tests, as well as for urinary GH excretion.
Methods: From the general population, 50 subjects were recruited, equally distributed according to sex and age between 20 and 70 years. Two consecutive 24-hour urine samples were collected to determine urinary GH. Plasma IGF-1 was measured as well as the GH response during an oral glucose tolerance test (OGTT) with 100 g glucose. Basal plasma IGF-1 was also measured in 250 subjects recruited likewise from the general population who had participated in previous studies on reference values.
Results: The following reference ranges were established: urinary GH < 5-46 microU/24 h; nadir GH after OGTT < or =1.5 mU/l for males and < or =2.0 mU/l for females. IGF-1 was divided into age groups: 20-30 years 8-61 nmol/l; 31-40 years 8-41 nmol/; 41-50 years 7-36 nmol/l; 51-60 years 5-37 nmol/l; and 61-70 years 7-27 nmol/l.
Conclusion: We have established reference values with state-of-the-art assay methodology for the diagnostic tests frequently used in the evaluation of patients suspected of acromegaly.
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Sensors (Basel)
December 2024
China Construction Steel Engineer Co., Ltd., Shenzhen 518118, China.
Structural design usually adopts uniform temperature action. However, during the actual construction of the structure, the temperature field acting on the structure is inhomogeneous. Therefore, the simulation of the construction of statically indeterminate steel structures considering only the uniform temperature field cannot truly reflect the temperature action after structural molding and the evolution of the stress performance of the temporary stress system of structural construction.
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December 2024
College of Physical Education and Health Engineering, Taiyuan University of Technology, Jinzhong 030600, China.
The application of dynamic data in biomechanics is crucial; traditional laboratory-level force measurement systems are precise, but they are costly and limited to fixed environments. To address these limitations, empirical evidence supports the widespread adoption of portable force-measuring platforms, with recommendations for their ongoing development and enhancement. Taiyuan University of Technology has collaborated with KunWei Sports Technology Co.
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December 2024
School of Resource and Environmental Engineering, Inner Mongolia University of Technology, Hohhot 010051, China.
The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety. However, there has been insufficient assessment of the health risks posed by chlorinated hydrocarbon contamination in groundwater around chemical industrial parks. This study evaluates the chlorinated hydrocarbon contamination in groundwater at a chemical park and conducts a multi-pathway health risk assessment, identifying the key risk pollutants.
View Article and Find Full Text PDFNutrients
December 2024
Aladina-MGU-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain.
: To obtain bioelectrical data to assess nutritional status for extremely low-birth-weight (ELBW) infants upon reaching term-corrected age. : A descriptive, observational, prospective, and single-center study, which included ELBW preterm infants was performed. The study variables collected were gestational age, sex, and anthropometry at birth and at term-corrected age.
View Article and Find Full Text PDFNutrients
December 2024
Faculty of Agriculture, Food Sciences and Environmental Management, Institute of Food Science, University of Debrecen, Böszörményi str. 138, 4032 Debrecen, Hungary.
Background/objectives: Baobab ( L.) is an underutilized species and edible parts (fruits, leaves and seeds) contribute to food security and human health in tropical areas. Although the fruits have attracted greater research interest and have recently been approved for consumption in EU countries, the leaves are traditionally consumed but they have yet to be studied from an interventional perspective.
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