AI Article Synopsis
- Four antimicrobial peptides were isolated from the skin of the Chinese brown frog, suggesting new sources for antimicrobial agents.
- The primary structures of these peptides were linked to the japonicin-2 family, previously found only in the Japanese brown frog.
- Although the most abundant peptide, japonicin-2CHa, was present in the extract, it showed less effectiveness against bacteria compared to the original japonicin-2 peptide, highlighting potential differences in antimicrobial potency within the family.
Article Abstract
Four structurally-related peptides with antimicrobial activity were isolated from an extract of the skin of the Chinese brown frog, Rana chaochiaoensis Liu, 1946. Determination of their primary structures revealed that they are members of the japonicin-2 family, previously identified only in the skin of the Japanese brown frog, R. japonica. Japonicin-2CHa (FVLPLLGILPKELCIVLKKNC) represented the most abundant peptide in the extract but its growth-inhibitory potency against Staphylococcus aureus (minimum inhibitory concentration, MIC=100 microM) and Escherichia coli (MIC>100 microM) was appreciably less than that of the more cationic japonicin-2 (FGLPMLSILPKALCILLKRKC). The high degree of structural similarity of japonicin-2CHb (VVPAFVLLKKAICIMLKRNC) with japonicin-2CHc (K9 --> R), and japonicin-2CHd (L16 --> F) is suggestive of recent gene duplication events. The data indicate a close phylogenetic relationship between R. chaochiaoensis and R. japonica but demonstrate that the species are not conspecific.
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| http://dx.doi.org/10.1016/j.cbpc.2006.07.007 | DOI Listing |
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