Purpose: Histopathologic study of conjunctival biopsy specimens in patients with or without exfoliation syndrome and mature cataract to reveal the presence of exfoliative material.
Material And Method: There were studied a group of patients with different ages who needed surgical cataract extraction; all patients were examined preoperative for the presence of exfoliation syndrome. The conjunctival biopsy specimens were obtained at the end of cataract surgical procedure in eyes both with exfoliation syndrome and in fellow eyes without clinical evidence of the disease.
Results: It has been recorded the presence of the exfoliative material in eyes both with exfoliation syndrome and in fellow eyes without clinical evidence of the disease.
Conclusions: Conjunctiva appears to be an independent source of exfoliation material with early detection in preclinical stage of exfoliation syndrome in fellow eyes that appeared to be clinically unaffected.
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BMC Ophthalmol
January 2025
Department of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Bahar Mah. Saim Çıkrıkcı Cad No: 59, Karabağlar, Turkey.
Background: The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes.
Methods: 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.
Sci Rep
January 2025
Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Kallam Anji Reddy Campus, 500034, Hyderabad, India.
To examine ultrastructural changes in the trabecular meshwork (TM) in patients with primary and secondary glaucoma using scanning electron microscopy (SEM). This was a qualitative descriptive hospital-based study on the ultrastructure of the TM. Pure TM samples were collected after microincisional trabeculectomy from 26 patients with primary or secondary glaucoma and 10 control samples from eye bank donor corneas.
View Article and Find Full Text PDFCureus
November 2024
Ophthalmology, All India Institute of Medical Sciences, New Delhi, IND.
Purpose: This study aims to analyze the outcomes of cases of abandoned cataract surgeries referred to a tertiary eye center.
Methods: This retrospective observational case series includes eleven cases referred to a tertiary eye center following abandoned cataract surgeries. The preoperative factors, intraoperative management, and postoperative outcomes were recorded and analyzed.
Int Ophthalmol
December 2024
Department of Ophthalmology, Beypazari State Hospital, Ankara, Turkey.
Purpose: To investigate the role of hematological and atherogenic biomarkers in evaluating systemic inflammation and cardiovascular risk in patients with pseudoexfoliation syndrome.
Methods: This retrospective study included 200 patients, 90 with pseudoexfoliation (PEX) syndrome (Group 1) and 110 healthy controls (Group 2). Twelve-hour fasting blood samples were collected to measure complete blood count, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) (neutrophil x platelet/lymphocyte), systemic inflammatory response index (SIRI) (neutrophil x monocyte/lymphocyte), pan-immune inflammation value (PIV) (neutrophil x platelet x monocyte/lymphocyte), C-reactive protein (CRP), uric acid, glucose, triglycerides (TG), total cholesterol, HDL, LDL, non-HDL, and triglyceride-glucose (TyG) index (Ln (TG [mg/dL] × glucose [mg/dL]/2)).
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
November 2024
Faculty of Medicine, University Clinic of Radiotherapy and Oncology, Skopje, Macedonia.
Purpose: To investigate the rare side effects of Osimertinib in a case of toxic epidermal necrosis.
Case Presentation: We report on a case of a 44-year old woman with lung adenocarcinoma harboring an EGFR-sensitizing mutation who was treated with Osimertinib as the second-line treatment. Ten days after Osimertinib initiation, a diffuse erythematous rash rapidly spread over the patient's trunk along with vesicles and purpuric macules; furthermore, she developed erythema and exfoliation on the face and trunk and severe mucositis.
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