Pulmonary sequestration is a rare congenital anomaly with nonfunctioning lung tissue, for which the arterial blood supply is usually derived from the thoracic or abdominal aorta. Surgical resection is the conventional treatment for pulmonary sequestration. The arterial embolization of pulmonary sequestration is an alternative technique and a less invasive treatment than conventional surgical resection. Here, we report two infants with intralobar and extralobar types of pulmonary sequestration, successfully treated with coil embolization of the feeding artery without any complications.

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Article Synopsis
  • Pulmonary sequestration is a rare congenital lung issue where abnormal lung tissue is supplied by a wrong artery, most commonly seen in the intralobar form.
  • Patients often experience symptoms like recurrent coughing up blood and lung infections.
  • Surgical treatment involves carefully removing the affected tissue while protecting healthy lung, with techniques to minimize the risk of bleeding from the abnormal arteries during the procedure.
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The objective of this study is to evaluate the clinical application and primary outcome of transcatheter embolization using Amplatzer™ Vascular Plug (AVP) Type 2 and Type 4 in different congenital cardiovascular malformations. This is a single-center retrospective observational cohort study. We analyzed clinical and imaging data of 36 patients retrospectively who received transcatheter embolizations of the following malformations using AVP: systemic-to-pulmonary collateral arteries (SPCA), patent ductus arteriosus (PDA), ventricular septal defects (VSD), and aberrant pulmonary sequestration arteries (PSA).

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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease.

Cell Host Microbe

December 2024

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, especially adherent-invasive Escherichia coli (AIEC). We previously demonstrated that AIEC producing the metallophore yersiniabactin (Ybt) promotes intestinal fibrosis in an IBD mouse model.

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Pulmonary sequestration (PS) is a rare congenital malformation where abnormal lung tissue lacks a connection to the airways and receives blood supply from systemic arteries. This case report describes a 30-year-old man with recurrent hemoptysis diagnosed with intralobar PS (ILS) as the cause. He underwent video-assisted thoracoscopic surgery to clip and section the aberrant artery, resulting in a successful outcome with no further bleeding.

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