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Acid triggering highly-efficient release of reactive oxygen species to block mitochondrial-mediated homeostasis maintenance for accelerating cell death.
Anal Chim Acta
February 2025
School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; School of Chemical and Environmental Engineering, Anhui Polytechnic University, 241000, Wuhu, PR China. Electronic address:
A pivotal pathway of photodynamic therapy (PDT) is to prompt mitochondrial damage by reactive oxygen species (ROS) generation, thus leading to cancer cell apoptosis. However, mitochondrial autophagy is induced during such a PDT process, which is a protective mechanism for cancer cell homeostasis, resulting in undermined therapeutic efficacy. Herein, we report a series of meticulously designed donor (D)-π-acceptor (A) photosensitizers (PSs), characterized by the strategic modulation of thiophene π-bridges, which exhibit unparalleled mitochondrial targeting proficiency.
View Article and Find Full Text PDFQuality appraisal of household recycling influences research found evidence was mostly insufficient for drawing conclusions.
Waste Manag
January 2025
Monash University, Behaviour Works Australia, Australia.
Research on recycling behaviour and its influences is critical to supporting public policy efforts to mitigate the negative effects of waste. However, recent reviews have raised concerns about the quality of recycling research. Despite this, no previous reviews have conducted quality appraisals.
View Article and Find Full Text PDFPlant Adaptation and Soil Shear Strength: Unraveling the Drought Legacy in .
Plants (Basel)
January 2025
Key Laboratory of Mountain Hazards and Earth Surface Processes, Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610299, China.
Climate change has led to an increasing frequency of droughts, potentially undermining soil stability. In such a changing environment, the shallow reinforcement effect of plant roots often fails to meet expectations. This study aims to explore whether this is associated with the alteration of plant traits as a response to environmental change.
View Article and Find Full Text PDFDeveloping a Versatile Arsenal: Novel Antimicrobials as Offensive Tools Against Pathogenic Bacteria.
Microorganisms
January 2025
Hainan Province Key Laboratory of One Health, School of Life and Health Sciences, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, China.
The pervasive and often indiscriminate use of antibiotics has accelerated the emergence of drug-resistant bacterial strains, thus presenting an acute threat to global public health. Despite a growing acknowledgment of the severity of this crisis, the current suite of strategies to mitigate antimicrobial resistance remains markedly inadequate. This paper asserts the paramount need for the swift development of groundbreaking antimicrobial strategies and provides a comprehensive review of an array of innovative techniques currently under scrutiny.
View Article and Find Full Text PDFNurses' health and work experiences during the COVID-19 pandemic in Swedish prehospital and hospital care: a deductive content analysis through the lens of the swAge model.
BMC Public Health
January 2025
Lund University, Lund, Sweden.
Working as a nurse offers job security but also poses risks for mental health issues. This study aims to explore factors and processes that affected health and work experiences among nurses in Sweden during the COVID-19 pandemic. Semi-structured interviews were conducted with 14 nurses from high COVID-19 patient load areas (ambulance, emergency departments, ICU, infection wards, and specialized COVID-19 wards).
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