The compatibility and biological efficacy of biomedical implants can be enhanced by coating their surface with appropriate agents. For predictable functioning of implants in situ, it is often desirable to obtain an extremely uniform coating thickness without effects on component dimensions or functions. Conventional coating techniques require rigorous processing conditions and often have limited adhesion and composition properties. In the present study, the authors report a novel precision electrospraying technique that allows both degradable and nondegradable coatings to be placed. Thin metallic slabs, springs, and biodegradable sintered microsphere scaffolds were coated with poly(lactide-co-glycolide) (PLAGA) using this technique. The effects of process parameters such as coating material concentration and applied voltage were studied using PLAGA and poly(ethylene glycol) coatings. Morphologies of coated surfaces were qualitatively characterized by scanning electron microscopy. Qualitative observations suggested that the coatings were composed of particles of various size/shape and agglomerates with different porous architectures. PLAGA coatings of uniform thickness were observed on all surfaces. Spherical nanoparticle poly(ethylene glycol) coatings (462-930 nm) were observed at all concentrations studied. This study found that the precision electrospraying technique is elegant, rapid, and reproducible with precise control over coating thickness (mum to mm) and is a useful alternative method for surface modification of biomedical implants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jbm.b.30641 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Liquid-based encapsulation for implantable bioelectronics across broad pH environments.
Nat Commun
January 2025
Department of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.
Wearable and implantable bioelectronics that can interface for extended periods with highly mobile organs and tissues across a broad pH range would be useful for various applications in basic biomedical research and clinical medicine. The encapsulation of these systems, however, presents a major challenge, as such devices require superior barrier performance against water and ion penetration in challenging pH environments while also maintaining flexibility and stretchability to match the physical properties of the surrounding tissue. Current encapsulation materials are often limited to near-neutral pH conditions, restricting their application range.
View Article and Find Full Text PDFEffects of thread design on soft and hard tissue healing around implants in lipopolysaccharide-induced peri-implantitis-like lesions in rat maxillae.
J Oral Biosci
January 2025
Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan. Electronic address:
Objectives: This study investigated the effects of thread design on the soft and hard tissues around implants in rat maxillary peri-implantitis-like lesions.
Methods: Fourteen, 9-week-old, female Wistar rats were used in this study. Two types of grade IV titanium tissue-level implants with a standard V-shape and buttress threads were prepared (control and test implants, respectively).
Effect of head size, head material, and radiation dose on the repeatability of CT-RSA measurements of femoral head penetration.
J Mech Behav Biomed Mater
January 2025
Division of Orthopaedic Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. Electronic address:
Background: The risk of early revision of total hip arthroplasty (THA) for polyethylene wear is now low, but there remains a need to perform wear measurements in patients for clinical surveillance. The gold standard of wear measurements has been radiostereometric analysis (RSA), which has limited availability. The use of computed tomography (CT) to perform THA wear measurement was described a decade ago and found to have acceptable accuracy and precision, but high radiation dose was a concern.
View Article and Find Full Text PDFEnhanced mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO, YO, and AlO as sintering aids.
J Mech Behav Biomed Mater
January 2025
School of Materials Science and Engineering, University of Jinan, Jinan, 250022, China. Electronic address:
Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.
View Article and Find Full Text PDFCalcium Phosphate (CaP) Composite Nanostructures on Polycaprolactone (PCL): Synergistic Effects on Antibacterial Activity and Osteoblast Behavior.
Polymers (Basel)
January 2025
Division of Mechanical Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan 54538, Jeonbuk, Republic of Korea.
Bone tissue engineering aims to develop biomaterials that are capable of effectively repairing and regenerating damaged bone tissue. Among the various polymers used in this field, polycaprolactone (PCL) is one of the most widely utilized. As a biocompatible polymer, PCL is easy to fabricate, cost-effective, and offers consistent quality control, making it a popular choice for biomedical applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!