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Topical Sunscreens: A Narrative Review for Contact Sensitivity, Potential Allergens, Clinical Evaluation, and Management for their Optimal Use in Clinical Practice.
Indian Dermatol Online J
October 2024
Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.
Topical sunscreens decrease the quantity of ultraviolet (UV) light from the sun reaching the skin by either blocking or scattering it and help protect the skin from dyspigmentation, photoaging, DNA damage, and photocarcinogenesis, especially in photosensitive individuals. The significant role played by visible light and infrared light in skin pigmentation and photoaging has been recognized in recent years. The majority of broad-spectrum sunscreens protect against UV-B (290-320nm) and UV-A (320-400nm) radiation.
View Article and Find Full Text PDFSynthesis of 2-Amino-'-aroyl(het)arylhydrazides, DNA Photocleavage, Molecular Docking and Cytotoxicity Studies against Melanoma CarB Cell Lines.
Molecules
January 2024
Laboratory of Organic, Bioorganic and Natural Product Chemistry, Molecular Biology and Genetics Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Diacylhydrazine bridged anthranilic acids with aryl and heteroaryl domains have been synthesized as the open flexible scaffold of arylamide quinazolinones in order to investigate flexibility versus rigidity towards DNA photocleavage and sensitivity. Most of the compounds have been synthesized via the in situ formation of their anthraniloyl chloride and subsequent reaction with the desired hydrazide and were obtained as precipitates, in moderate yields. All compounds showed high UV-A light absorption and are eligible for DNA photocleavage studies under this "harmless" irradiation.
View Article and Find Full Text PDFUltraviolet light affects the color vocabulary: evidence from 834 languages.
Front Psychol
June 2023
Department of Catalan Philology and General Linguistics, University of Barcelona, Barcelona, Spain.
It has been suggested that people living in regions with a high incidence of ultraviolet light, particularly in the B band (UV-B), suffer a phototoxic effect during their lifetime. This effect, known as lens brunescence, negatively impacts the perception of visible light in the "blue" part of the spectrum, which, in turn, reduces the probability that the lexicon of languages spoken in such regions contains a word specifically denoting "blue." This hypothesis has been recently tested using a database of 142 unique populations/languages using advanced statistical methods, finding strong support.
View Article and Find Full Text PDFSynergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis.
Int J Mol Sci
February 2023
Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Pterygium is a multifactorial disease in which UV-B is speculated to play a key role by inducing oxidative stress and phototoxic DNA damage. In search for candidate molecules that are useful for justifying the intense epithelial proliferation observed in pterygium, our attention has been focused on Insulin-like Growth Factor 2 (IGF-2), mainly detected in embryonic and fetal somatic tissues, which regulate metabolic and mitogenic functions. The binding between IGF-2 and its receptor Insulin-like Growth Factor 1 Receptor (IGF-1R) activates the PI3K-AKT pathway, which leads to the regulation of cell growth, differentiation, and the expression of specific genes.
View Article and Find Full Text PDFCytoprotective Effects of Water Soluble Dihydropyrimidinthione Derivative Against UV-B Induced Human Corneal Epithelial Cell Photodamage.
Front Pharmacol
October 2021
Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan University School of Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Excessive UV-B exposure is well known to be a risk factor for corneal phototoxicity including direct DNA damage and disturbances in the antioxidant balance. Here, we showed a successful synthesis of a water-soluble and biocompatible small molecule with dihydropyrimidinthione skeleton, which could effectively protect human corneal epithelial (HCE-2) cells from UV-B damage. In separate experiments, absorbed UV-B rays and exhibited scavenging activity against intracellular ROS induced by UV-B radiation, thereby reducing the levels of DNA fragmentation.
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