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Doxycycline Suppresses Vasculogenic Mimicry in Human Pterygium Fibroblasts.
Curr Eye Res
October 2022
Eye Institute, Affiliated Hospital of Nantong University, Nantong, China.
Purpose: To explore the effect of doxycycline on vasculogenic mimicry (VM) formation and the potential mechanism in human pterygium fibroblasts in order to find novel targets for pterygium therapy.
Methods: First, we demonstrate the existence of VM in 73 pterygium specimens by CD31 and periodic acid Schiff (PAS) dual staining. Then we used cell counting kit-8, clone formation assay and flow cytometry to prove the inhibitory effect of doxycycline on cell proliferation and apoptosis.
A Case of Doxycycline-induced Melanin in the Gingiva Tissue: Case Report.
Curr Drug Saf
June 2023
Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
Background: Gingival pigmentation is a discoloration of the gingiva due to a variety of lesions and conditions associated with several endogenous and exogenous etiologic features.
Objective: The purpose of this study is to describe a report of gingival pigmentation in a patient who used doxycycline.
Case Report: A 21-year-old Caucasian female was under dermatological treatment and antibiotic therapy with doxycycline 100 mg (one time a day) for 90 days.
Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung.
Antioxidants (Basel)
January 2022
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
Paraquat (PQ) is an agrochemical known to cause pulmonary fibrosis. PQ-induced collagen deposition in the lung is thought to require enzymatic formation of PQ radicals, but the specific enzymes responsible for this bioactivation event in vivo have not been identified. We tested the hypothesis that lung P450 oxidoreductase (POR or CPR) is important in PQ-induced lung fibrosis in mice.
View Article and Find Full Text PDFAn Improved Vector System for Homogeneous and Stable Gene Regulation.
Int J Mol Sci
May 2021
Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Precise analysis of the genetic expression and functioning of proteins requires experimental approaches that, among others, enable tight control of gene expression at the transcriptional level. Doxycycline-induced Tet-On/Tet-Off expression systems provide such an opportunity, and are frequently used to regulate the activity of genes in eukaryotic cells. Since its development, the Tet-system has evolved tight gene control in mammalian cells; however, some challenges are still unaddressed.
View Article and Find Full Text PDFDoxycycline-induced staining of teeth and malar rash in a child.
J Postgrad Med
November 2020
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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