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Addisonian Pigmentation - The Great Mimicker - A Review.
Indian J Dermatol
October 2024
Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.
Skin colour usually depends upon melanin, haemoglobin, and carotenoids. Pigmentary disorders indicate an increased amount of melanin, leading to a darker colour of the skin, called hypermelanosis. Addison's disease is a rare endocrinal disorder with severe oral and systemic manifestations.
View Article and Find Full Text PDFTriple inhaled therapy in asthma: Beliefs, behaviours and doubts.
Pulm Pharmacol Ther
December 2024
Respiratory Diseases and Allergy Department, IRCCS Polyclinic Hospital San Martino, Genoa, Italy; Department of Internal Medicine (DiMI), University of Genoa, Italy. Electronic address:
Long-acting muscarinic antagonists (LAMA) in association with inhaled corticosteroids (ICS) plus long-acting beta-2 agonists (LABA) are recommended by the GINA report as further option in step 4 and first choice in step 5 treatment. Despite consistent evidence of its efficacy and safety, inhaled triple therapy (ITT) is still not largely used in patients with asthma. With the aim to explore belief and behaviours of asthma specialists, an ad hoc survey has been developed by a panel of Interasma Scientific Network (INESnet) experts and subsequently defined by two Delphi rounds among an international group of physicians.
View Article and Find Full Text PDFDisseminated Tuberculosis Masquerading as a Uterine Cervical Mass in an Immunocompetent Young Female: A Case Report.
Cureus
October 2024
Internal Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Concurrent tubercular involvement of two or more non-contiguous organs is termed disseminated tuberculosis (TB) and is rare in immunocompetent patients. We describe the case of a young immunocompetent woman with disseminated TB who presented with primary complaints of amenorrhea and dysuria. Abdominal ultrasound showed a uterine cervical mass, which on histopathological evaluation revealed epithelioid granulomata with Langhans giant cells and acid-fast bacilli (AFB).
View Article and Find Full Text PDFCOVID-19 Infection in Adrenal Tuberculosis Patients with Adrenal Insufficiency Who Complicated with Adrenal Crisis.
Acta Med Indones
July 2024
Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Article Synopsis
- * A 52-year-old woman with a history of suspected primary adrenal insufficiency and poor treatment compliance was admitted with worsening symptoms, later diagnosed with adrenal crisis amid her COVID-19 infection.
- * Diagnosis of adrenal insufficiency is complex due to non-specific symptoms; education and proper guidelines are essential for prevention, while further testing is needed to determine the root cause of her condition.
The effect of corticosteroids in developing active pulmonary tuberculosis among patients with COVID-19.
PLoS One
October 2024
Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand.
Article Synopsis
- * A study conducted at King Chulalongkorn Memorial Hospital analyzed 243 COVID-19 patients on high-dose corticosteroids, revealing that 1.6% developed TB within a year, with higher incidences among those with chronic kidney and lung diseases.
- * The mortality rate for patients with TB was significantly higher (50%) compared to those without TB (0.4%), suggesting a need for routine screening for latent TB in COVID-19 patients receiving high-dose corticosteroids to prevent severe outcomes.
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